Cellular Responses to Adversity: Oxidative Stress and Protection Against Oxidative Damage

血红素加氧酶-1蛋白的缺乏会在动物和人类中引起严重的生物学后果。这些包括生殖能力下降，发育迟缓，身体无法处理铁，慢性炎症和增加对年龄相关疾病的易感性。这项研究将确定蛋白质的缺乏如何在基因，蛋白质和蛋白质功能水平上改变细胞。通过这样做，该项目将阐明血红素加氧酶-1如何以有益的方式改变细胞功能。这些信息最终将有助于预防与血红素加氧酶-1缺乏相关的严重疾病。它还将为减缓年龄相关疾病的新疗法提供基础。

A deficiency in the protein haem oxygenase-1 causes severe biological consequences in animals and humans. These include decreased reproduction, retarded development, the inability of the body to handle iron, chronic inflammation and increased susceptibility to age-associated diseases. This study will determine how a deficiency of the protein alters cells at the level of genes, proteins and protein functions. By doing so, the project will illuminate how haem oxygenase-1 alters cell functions in a beneficial way. This information will eventually assist in preventing the serious disorders associated with deficiency of haem oxygenase-1. It will also provide the basis for novel treatments to slow down age-associated diseases.