How do cells regulate the synthesis and localisation of coenzyme Q?

细胞如何调节辅酶Q的合成和定位？

• 批准号: DP150102408
• 负责人: Prof Roland Stocker
• 金额: $ 28.58万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102408
• 关键词: How; do; cells; regulate; synthesis

The aims of this project are to identify how cells regulate the synthesis and the distribution of coenzyme Q between different organelles, and how these processes are affected when cells experience various conditions of stress. Coenzyme Q is a fat-soluble molecule present in all cell membranes and essential for normal cell function. Despite this, relatively little is known about the systems that regulate the synthesis and cellular location of coenzyme Q. The project plans to identify the genes and proteins required for coenzyme Q regulation of sub-cellular distribution in unstressed and stressed cells. In doing so, the project could provide a greater understanding of the ways cells maintain normal coenzyme Q levels and respond to stress.

该项目的目的是确定细胞如何调节辅酶Q在不同细胞器之间的合成和分布，以及当细胞经历各种应激条件时，这些过程如何受到影响。辅酶Q是一种脂溶性分子，存在于所有细胞膜中，对正常细胞功能至关重要。尽管如此，对辅酶Q的合成和细胞定位的调节系统知之甚少。该项目计划确定辅酶Q调节非应激和应激细胞中亚细胞分布所需的基因和蛋白质。通过这样做，该项目可以更好地了解细胞维持正常辅酶Q水平和应对压力的方式。