NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies

NOX 酶作为炎症引发的神经变性的介质：调节 NOX 酶作为新疗法

• 批准号: nhmrc : 1037879
• 负责人: Prof Roland Stocker
• 金额: $ 66.34万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nox-enzymes-mediators-novel-therapies/111105
• 关键词: NOX; enzymes; mediators; inflammation; triggered

The NEURINOX project aims at identifying novel therapeutic targets for neurodegenerative diseases; an increasing health issue for the ageing Australian population. NADPH oxidases (NOX) enzymes, generate reactive oxygen species, and are key regulators of neuroinflammation. Inflammatory dysregulation is characterized by a change in NOX activity. NEURINOX will expound the links between neuroinflammation, NOX enzyme activity & neurodegenerative diseases to identify novel therapeutic targets to treat neuroinflammation.

NEURINOX项目旨在确定神经退行性疾病的新治疗靶点，这是澳大利亚老龄人口日益严重的健康问题。NADPH氧化酶（NOX）酶，产生活性氧，是神经炎症的关键调节因子。炎症失调的特征在于NOX活性的变化。NEURINOX将阐述神经炎症，NOX酶活性和神经退行性疾病之间的联系，以确定治疗神经炎症的新治疗靶点。