Workshop On: Micro/Nanoelectronics: Devices and Technologies for Biomedical Applications. The Workshop will be held at IMEC in Leuven, Belgium from September 25-26, 2008.

摘要目的这项提案的目的是申请资金支持一个研讨会，该研讨会旨在加快微/纳米电子设备的开发，以改善医疗保健。研讨会将于2008年9月25日至26日在比利时鲁汶的跨学科微电子中心(IMEC)举行。研讨会将汇集来自微系统和纳米生物技术社区的领先研究人员，以确定重大挑战，促进合作，并推荐加快这些技术在生物学和生物医学中使用所需的研究。这次研讨会将汇集来自MICR/Nano社区以及生物学和生物医学的科学家和工程师，并将试图确定可用于体内和体外应用的设备和系统。这两个学科似乎注定要在细胞层面相遇，这次研讨会试图弥合它们之间的差距。智慧的优点：经过近40年的发展，许多医疗保健所需的微电子技术现在正在涌现。涉及数百万个晶体管的复杂信号处理任务可以在一个微瓦级别的单个芯片上执行。无线技术创造了全球通信网络，并正在被简化为能够在体内工作的单个芯片。基于MEMS的传感器现在存在许多生理参数，适用于植入物的密封式晶圆级封装技术正在出现。基于纳米技术的结构正在与微流体相结合，并被开发用于分析脱氧核糖核酸和筛选阿尔茨海默病、S病、心脏病和癌症的蛋白质组生物标记物。但许多挑战依然存在。需要改进的电源，其中一些可能是基于能量清除，生物环境和物理监测设备之间的关键接口必须得到更好的理解。医疗保健的真正进步很可能需要两者的整合。更广泛的影响：医疗保健是21世纪面临的最重要问题之一。2000年，塞拉利昂的预期寿命从35岁到美国的77岁和日本的83岁不等，美国的医疗保健成本占GDP的13%。全球60岁以上的人口约为6.3亿，但到2050年，这一数字将增加到20亿以上，增幅为330%。显然，必须采取措施避免灾难性的医疗成本。基于细胞/分子分析的诊断设备和用于治疗许多最严重的慢性疾病的植入式微系统是应对这些挑战的最有希望的方法之一。

AbstractObjective This objective of this proposal is to request funding to support a workshop aimed at speeding the development of micro/nanoelectronic devices for improved healthcare. The workshop will be held at the Interdisciplinary Microelectronics Center (IMEC) in Leuven, Belgium on September 25-26, 2008. The workshop will bring together leading researchers from the microsystem and nanobiotechnology communities to identify grand challenges, promote collaborations, and recommend research needed to speed the use of these technologies in biology and biomedicine. This workshop will bring together scientists and engineers from micr/nano communities and biology and biomedicine and will try to identify devices and systems that could be used for in-vivo and in-vitro applications. The two disciplines seem destined to meet at cellular dimensions, and this workshop seeks to bridge the gap between them.Intellectual Merit:After nearly four decades, many of the microelectronic technologies needed for health care are now emerging. Sophisticated signal processing tasks involving millions of transistors can be performed on a single chip at microwatt levels. Wireless technology has created global communication networks and is being reduced to single chips capable of working in-vivo. MEMS-based sensors now exist for many physiological parameters, and hermetic wafer-level packaging techniques suitable for use in implants are emerging. Structures based on nanotechnology are being combined with microfluidics and being developed to analyze DNA and screen for proteomic biomarkers of Alzheimer?s disease, heart disease, and cancer. But many challenges remain. Improved power sources are needed, some perhaps based on energy scavenging, and the critical interface between the biological environment and physical monitoring devices must be much better understood. True advances in health care will likely require the integration of both. Broader impact:Health care is one of the most important problems confronting the 21st century. In 2000, life expectancies ranged from 35 years in Sierra Leone to 77 in the U.S. and 83 in Japan, and in U.S. the cost of health care represented 13% of GDP. About 630 million people worldwide were over the age of 60, but by 2050 this number will increase to over two billion, an increase of 330%. Clearly something must be done to avoid catastrophic health care cost. Diagnostic devices based on cellular/molecular analysis and implantable microsystems for treating many of our most serious chronic disorders are among the most promising approaches for meeting these challenges.