RUI: Radical Reactions of Transition Metal-Arene Complexes

该项目将继续致力于开发利用以前未发现的自由基过程形成C-C键的方法。更具体地说，该项目将研究有机化学两个重要分支学科的界面反应，基于自由基的有机合成和过渡金属-芳烃配合物。虽然过渡金属已被广泛用于修饰结合有机分子的离子反应性，但对这种体系的自由基反应的研究却很少。本项目将通过对一系列过渡金属配合物的系统研究来解决化学文献中的这一缺陷，以确定它们在自由基过程中的效用。有了这个奖项，有机和大分子化学项目支持了米德尔伯里学院化学和生物化学系杰弗里·拜尔斯教授和六名本科生暑期研究助理的研究。由于过渡金属促进过程和自由基过程对化学工业都具有重要意义，因此这项工作可以为高效生成具有广泛适用性和重要性的复杂分子开辟新的途径。这种方法的可能应用包括与石化工业相关的任何学科，包括制药、农业化学和材料科学等不同领域。

This project will continue work on the development of methods for the formation of C-C bonds using previously undiscovered radical processes. More specifically, the project will study reactions at the interface of two important subdisciplines of organic chemistry, radical-based organic synthesis and transition metal-arene complexes. While transition metals have been used extensively to modify the ionic reactivity of bound organic molecules, very little study has been made of the radical reactions of such systems. This project will address this shortcoming in the chemical literature through the systematic study of a series of transition metal complexes to determine their utility in radical processes.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jeffrey Byers and six undergraduate summer research assistants in the Department of Chemistry and Biochemistry at Middlebury College. Since both transition metal-promoted processes and radical processes are of significant importance to the chemical industry, this work could open up new avenues for the efficient generation of complex molecules of broad applicability and importance. The possible applications of this methodology include any of the disciplines related to the petrochemical industry, including such diverse fields as pharmaceuticals, agricultural chemicals, and materials science.