Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for Hyperthermia

ID：MPS/dmr/bmat(7623)0907167 PI：Mford，Olin T.ORG：Clemson University标题：研究聚合物包裹磁性纳米颗粒的尺寸效应对高温下磁性纳米颗粒弛豫速率的影响电子优点：PI建议调查影响纳米聚合物包裹磁性氧化物颗粒磁热的因素。磁性粒子从外加的电磁辐射中获得热能，如果这些粒子可以靶向癌细胞，则可以通过将它们加热到中等温度(40摄氏度)而杀死这些细胞，而不会损害周围组织。颗粒-涂层复合体对交变电磁场的响应速度与其弛豫时间有关，控制这种行为的材料问题尚未完全了解。拟议研究的一个主要目标是对松弛机制有一个基本的了解。磁芯的大小和聚合物稳定层的大小对这些材料对电磁辐射的响应都有很大的影响。然而，这两个维度的比例如何影响对不同磁场和磁场频率的热响应还没有被很好地理解。PI建议开发涂层和非涂层磁性纳米粒子的模型系统，测量核心粒子和聚合物/粒子复合体的尺寸和尺寸分布如何影响悬浮液的松弛速率，测量不同纳米粒子系统在与人体中发现的类似的溶剂系统中的升温速率，并定制磁芯和聚合物刷子的尺寸以优化在特定加热频率和场下的加热。这项工作为制药公司开发基于纳米颗粒的新疗法和显像剂提供了基础。一个成功的结果将不仅影响热疗研究，而且还将影响磁性、聚合物化学和胶体化学。该项目位于物理、化学和生物的交叉点，因此为学生的跨学科培养提供了一个平台。除了该项目的研究生外，它还将为两名本科生提供研究机会。良好的写作和口头表达能力的培养对未来科学家和工程师的发展至关重要。该项目的目标之一是为学生提供在国内和国际会议上展示他们的工作的机会。国际和平研究所将参加J.E.瑟林暑期项目，该项目让南卡罗来纳州的高中生接触材料科学研究。预计他的团队将指导其中两名学生。这项工作的目标之一是为克莱姆森的代表开发教学工具，让他们走遍东南部，教育高中生进行生物材料的研究。

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson UniversityTitle: Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for HyperthermiaINTELLECTUAL MERIT: The PI proposes to investigate the factors affecting magnetic hyperthermia in nano-scale polymer-coated magnetic oxide particles. Magnetic particles acquire thermal energy from applied electromagnetic radiation and if the particles can be targeted into cancerous cells these cells can be killed by heating them to moderate temperatures ( 40 °C) without harming the surrounding tissue. The rate of response of the particle-coating complex to an alternating electromagnetic (EM) field is related to its relaxation time, and the materials issues that govern this behavior are not fully understood. A major objective of the proposed research is the acquisition of a fundamental understanding of the relaxation mechanisms. The sizes of the magnetic core and polymeric stabilizing layer can both greatly influence the response of these materials to EM radiation. However, it is not well understood how the ratio of these two dimensions affects the thermal response to different magnetic fields and field frequencies. The PI proposes to develop model systems of coated and non-coated magnetic nanoparticles, measure how the sizes and size distributions of the core particles and the polymer/particle complexes affect the relaxation rates of the suspensions, measure the heating rates of different nanoparticle systems in solvent systems similar to those found in the human body and tailor the sizes of the magnetic core and the polymer brushes to optimize heating at specific heating frequencies and fields.BROADER IMPACTS: The topic of the proposal is of current interest, and there will be abundant opportunities for dissemination of results in conferences and in publications. The work provides a foundation for pharmaceutical companies to develop new nanoparticle-based therapies and imaging agents. A successful outcome will impact not only hyperthermia research but also magnetism, polymer chemistry, and colloid chemistry. This project is at the intersection of physics, chemistry, and biology and thus provides a platform for interdisciplinary training of students. In addition to the graduate students on the project, it will provide opportunities for two undergraduate research students. The development of good writing and oral presentation skills is critical for the development of future scientists and engineers. One of the goals of the project is to provide opportunities for the students to present their work at national and international meetings. The PI will participate in the J. E. Sirrine Summer Program that exposes South Carolina high-school students to materials science research. It is expected that his group will mentor two of these students. One of the goals of this work is to develop teaching tools for Clemson representatives to travel across the Southeast to educate high school students on research in bionanomaterials.