Redox Neutral Reaction Cascades: Bond Forming Hydride Shift Processes

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。这个项目探索了导致简单的C-H键官能化的反应级联。重点是研究由分子内或分子间氢化物移动事件引发的反应级联，这些事件导致亲水性/亲核性对的形成。亲水性和亲核性的结合导致分子复杂性的快速增加，而不会产生副产物。使用催化方法是这些研究的一个组成部分，作为降低活化障碍和允许发现具有广泛适用性的未知重排的一种手段。一个重要的目标是开发氢化物变换反应的催化对映选择性变体。凭借这一奖项，有机和高分子化学计划支持新泽西州立大学罗格斯大学化学和化学生物学系的Daniel Seidel教授的研究。塞德尔教授的研究工作围绕着有机合成的简便方法的开发，重点是不对称催化。这种化学将有助于开发对环境无害的化学合成方法。该方法的成功开发将使人们能够迅速获得与制药和农业相关的有价值的化合物。此外，该项目还为化学科学领域的下一代研究人员提供了理想的培训场所。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project explores reaction cascades that lead to facile C-H bond functionalization. The focus is on studying reaction cascades that are initiated by intra- or intermolecular hydride shift events that result in the formation of an electrophile/nucleophile pair. Subsequent combination of electrophile and nucleophile leads to the rapid increase of molecular complexity without the generation of byproducts. The use of catalytic approaches is an integral part of these investigations as a means of lowering activation barriers and to allow for the discovery of yet unknown rearrangements of broad applicability. An important goal is the development of catalytic enantioselective variants of hydride shift reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Daniel Seidel of the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey. Professor Seidel's research efforts revolve around the development of facile methods for organic synthesis with an emphasis on asymmetric catalysis. Such chemistry will contribute to environmentally benign methods for chemical synthesis. The successful development of the methodology will provide rapid access to valuable compounds of relevance to the pharmaceutical and agricultural industries. Furthermore, this project provides an ideal training ground to prepare the next generation of researchers in the chemical sciences.