CSTORMS: The Center for Oceans and Human Health Research in Marine Sciences

海洋和人类健康（OHH）中心的国家网络的建立五年前创造了一个机会，为迈阿密大学巩固和重定向医学院（米勒医学院）和海洋学校（海洋和大气科学罗森斯蒂尔学院，RSMAS）之间正在进行的合作。迈阿密大学的战略是，将研究工作重点放在有害藻华和娱乐海洋沃茨的微生物污染问题上，在现有合作努力的基础上，寻找新的研究人员，将海洋学和生物医学科学活动的优势结合起来。在过去的五年中，我们通过杠杆资金和新的研究人员的参与，大大扩大了我们的海洋和人类健康中心的原有广度。特别是在微生物污染领域，我们进行了人类健康和接触研究，在微生物成分中建立了预测数学模型，并在微生物成分中加入了耐甲氧西林金黄色葡萄球菌;在有害生物领域，我们已经证明神经毒性氨基酸β-N-甲氨基-L-丙氨酸（BMAA）可能是食物网中的一种重要毒素，我们已经建立了诊断和预测模型，显示了佛罗里达赤潮的新来源。在这项基于成果的更新的资助下，迈阿密大学OHH中心在未来两年的研究将建立和扩展中心研究的两个重要领域：1）模拟亚热带环境中非点源海滩海岸线的微生物运输以及该海滩和近岸环境中的病原体行为;（2）进一步探讨海洋食物链中的有害赤潮生物及其毒素，重点是与蓝绿色藻类（蓝藻）有关的水溶性神经毒素BMAA和与佛罗里达赤潮生物Karenia brevis有关的亲脂性神经毒素短尾藻毒素。 更广泛的影响： UM OHH中心未来两年的研究将提供：a）海滩地点水质状况的实时预测建模工具以及病原体和沙子的重要数据; B）探索海洋食物链中两种重要但不同的HAB毒素的毒素转移程度。这些研究活动将得到海洋和人类健康方面的培训和外联活动的支持。研究生将在这两个研究项目的支持。将有一个OHH计划，为本科生提供与研究项目及其调查人员合作的机会。机会也将提供给OHH中心的调查人员和学生前往国内和国际上提出他们的OHH研究的结果，并与其他OHH中心在科学会议（包括在第二次OHH戈登研究会议和研究生研究研讨会在2010年6月参与）互动，以及与来访的OHH科学家由该中心赞助的互动。该中心将继续支持佛罗里达毒物信息中心的全年无休、365天的水生毒素免费热线（888-232-8635），向医疗保健提供者、患者和公众提供有关有害藻华暴露和健康影响的信息，并扩大该中心网站（www.rsmas.miami.edu/groups/ohh/）的使用和传播。最后，该中心的研究人员参与扩展和传播正在进行的海洋与人类健康研究生和高年级本科课程，以及开发关于海洋和人类健康的社会经济影响和人类福祉的新教科书。

The establishment of a national network of Oceans and Human Health (OHH) centers five years ago created an opportunity for the University of Miami to consolidate and redirect its ongoing collaborations between the Medical School (Miller School of Medicine) and the Marine School (Rosenstiel School of Marine and Atmospheric Science, RSMAS). Focusing research efforts on issues of harmful algal blooms (HABs) and microbial pollution of recreational marine waters, the University of Miami strategy has been to build upon existing cooperative efforts and seek out new researchers, blending strengths from those activities in oceanography and biomedical sciences. In the course of the last five years, we have expanded the original breadth of our Oceans and Human Health Center substantially through leveraged funding and involving new researchers. In particular, in the area of microbial pollution, we have performed human health and exposure studies with predictive mathematical modeling in the microbe component and added methacillin-resistant Staphylococcus aureas to the microbe component; and in the area of HABs, we have demonstrated that the neurotoxic amino acid, beta-N-methylamino-L-alanine (BMAA), may be an important toxin in the food web, and we have developed diagnostic and prognostic modeling showing a new source for Florida red tide blooms. With funding from this Accomplishment-based Renewal, research at the University of Miami OHH Center over the next two years will build and expand on two important ongoing areas of Center research: 1) the modeling of the transport of microbes from the shoreline of a nonpoint source beach within a sub/tropical environment as well as pathogen behavior in this beach and near-shore environment; and 2) further exploration of HAB organisms and their toxins in the marine food chain, focusing on the water soluble neurotoxin, BMAA, associated with blue green algae (cyanobacteria) and the lipophilic neurotoxin, brevetoxin, associated with the Florida red tide organism, Karenia brevis. Broader Impacts: Research for the next two years of the UM OHH Center will provide: a) a real-time predictive modeling tool for water quality conditions at beach sites as well as important data on pathogens and sand; b) the exploration of the extent of toxin transfer within the marine food chain of two important but different HAB toxins. These research activities will be supported by training and outreach in oceans and human health. Graduate students will be supported in both research projects. There will be an OHH Program to provide undergraduates with the opportunity to work with the Research Projects and their investigators. Opportunities will also be made available for OHH Center investigators and students to travel nationally and internationally to present the results of their OHH research and interact with the other OHH Centers in scientific conferences (including participation in the Second OHH Gordon Research Conference and Graduate Research Seminar in June 2010), as well as interact with visiting OHH Scientists sponsored by the Center. The Center will continue to support the 24/7, 365 day/yr toll-free Aquatic Toxins Hotline (888-232-8635) at the Florida Poison Information Center to provide information on harmful algal bloom exposures and health effects to healthcare providers, patients and the general public, as well as expand the uses and dissemination of the Center Website (www.rsmas.miami.edu/groups/ohh/). Finally, the Center researchers are involved in expanding and disseminating an ongoing graduate and upper level undergraduate course in Oceans and Human Health, and the development of a new Textbook on the Socio-Economic Impacts and Human Wellbeing in Oceans and Human Health.