Acquisition of a Low-Field NMR Spectrometer for Research and Teaching

凭借化学研究仪器和设施：部门多用户仪器计划（CRIF：MU）的这一奖项，马丁L。放大图片作者：Richard肯普，帕特里克S.罗伯特·T·马里亚诺来自新墨西哥州大学化学和化学生物学系的潘恩和王伟将获得一台低场（300 MHz）多核NMR光谱仪。该工具将用于支持研究活动，例如：1）允许逐步（逐原子）组装富含13、14和15族元素的新族主族元素环和多环笼化合物; 2）活化和固定小分子如二氧化碳、COS、二硫化碳和氧以产生更有价值的产物; 3）使用后过渡金属钳形络合物的环氧化物和其它部分氧化的有机物的均相催化路线; 4）合成中间体和天然和非天然产物的结构和立体化学表征; 5）贾第鞭毛虫生长抑制剂的合理设计以及磷蛋白的研究; 6）研究作为分子线装置的潜在组分的供体-桥-受体系统，和7）合成蛋白质胆固醇酯酶、乳酸脱氢酶、NfKB、尿激酶、醛糖还原酶的新抑制剂，HIV蛋白酶和Abeta聚集体。多核NMR光谱是化学和生物化学研究中必不可少的分析工具。 光谱使研究人员能够识别未知物质，并通过检测原子核自旋特性引起的能级之间的跃迁，提供从小分子到大蛋白质的原子排列和结构信息。 该光谱仪将加强调查人员和学生的许多研究活动，其中许多人来自代表性不足的群体。

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professors Martin L. Kirk, Richard Kemp, Patrick S. Mariano, Robert T. Paine and Wei Wang from the Department of Chemistry and Chemical Biology at the University of New Mexico will acquire a low-field (300 MHz) multinuclear NMR spectrometer. The instrument will be used to support research activities such as: 1) synthetic methodologies that allow for step by-step (atom-by-atom) assembly of new families of main group element ring and polycyclic cage compounds rich in Group 13, 14 and 15 elements; 2) activation and fixing of small molecules such as carbon dioxide, COS, carbon disulfide, and oxygen to produce more valuable products; 3) homogeneous catalytic routes to epoxides and other partially-oxidized organics using late transition metal pincer complexes; 4) characterization of structures and stereochemistry of synthetic intermediates and natural and non-natural products; 5) rational design of Giardia lamblia growth inhibitors as well as study of phosphoproteins; 6) study of donor-bridge-acceptor systems as potential components of molecular wire devices and, 7) synthesis of new inhibitors of the proteins cholesterol esterase, lactate dehydrogenase, NfKB, urokinase, aldose reductase, HIV protease and Abeta aggregates.Multinuclear NMR spectroscopy is an essential analytical tool in chemistry and biochemistry research. The spectra enable researchers to identify unknown substances and to provide information on the atom arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This spectrometer will enhance many research activities of investigators and students, many of whom are from underrepresented groups.