Acquisition of Equipment for Screening Catalytic Reactions at High-Pressure

有了化学研究仪器和设施奖：系多用户仪器计划(CRIF：MU)，威斯康星大学化学系的Robert Hamers、Clark R.Landis和Shannan S.Stahl将获得研究高压(50-3000 psig)下进行的溶液化学反应和催化过程的设备。该设备包括可通过红外光谱监测反应动力学的反应器和适用于在高压下筛选反应的衰减全反射。该设备将用于研究高压下与空气敏感试剂的反应或在厌氧条件下的反应，包括催化氢甲酰化、聚合和羰基化反应，以及氧化反应、高温化学和一氧化二氮化学的研究。高压反应在化工和制药工业中具有广泛的意义，包括一些最重要的大型化工过程：好氧氧化、加氢和烯烃聚合。这种类型的新反应和对现有反应的基本见解对于推动该领域的发展至关重要；然而，由于需要使用确保安全的专门设备，此类研究变得复杂。该提案所要求的设备将能够在高压下发现各种化学反应并对其进行机械研究。学生将接受在研究和课程工作中正确使用这种设备的培训，以改善他们为在化学和制药行业工作做准备

AbstractWith this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Robert Hamers, Clark R. Landis and Shannan S. Stahl of the University of Wisconsin Department of Chemistry will acquire equipment to study solution-phase chemical reactions and catalytic processes performed at high pressures (50-3000 psig). The equipment includes reactors which allow monitoring reaction kinetics by infrared spectroscopy and attenuated total reflectance suitable for screening of reactions at high pressure. The equipment will be used to investigate at high pressures reactions with air-sensitive reagents or under anaerobic conditions including catalytic hydroformylation, polymerization and carbonylation reactions, and the study of oxidative reactions, high temperature chemistry and nitrous oxide chemistry. High-pressure reactions have widespread significance in the chemical and pharmaceutical industries and include some of the most important large scale chemical processes: aerobic oxidation, hydrogenation and alkene polymerization. New reactions of this type and fundamental insights into existing reactions are critical to advance the field; however, such studies are complicated by the need to use specialized equipment that ensures safety. The equipment requested in this proposal will enable the discovery and mechanistic investigation of a wide range of chemical reactions under high-pressure. Students will be trained in the proper use of this equipment in their research and in course work improving their preparation for jobs in the chemical and pharmaceutical industries