Engineering Metal-Organic Framework Catalysts using Postsynthetic Modification

化学催化计划支持教授塞思M。科恩在加州大学圣地亚哥分校的一个研究项目，该项目将使用合成后修饰（PSM）来改变金属有机框架（MOF）材料，以引入一系列功能，而不会破坏MOF的整体结构和孔隙率。合成后修饰作为一种有用的工具正在出现，以获得不能直接制备的功能化的MOFs。这些材料可用作均相和非均相催化剂。虽然现在有相当多的MOFs被用作非均相催化剂的例子，但该提案正确地将催化确定为MOFs化学的一个发展不足的领域。初步研究表明，手性取代基，有机催化基团（羧酸，脲），和金属结合基团可以很容易地引入到MOFs的PSM。早期的研究表明，这些改性的MOFs对催化反应很有用。在美国国家科学基金会化学部化学催化计划的支持下，科恩博士将进行研究，为金属有机框架（MOFs）作为能源、催化和生物医学应用的首选材料做出贡献。基于这些技术应用，并且由于MOFs的合成后修饰（PSM）的重要性日益增加，Cohen教授的工作已经引起了直接MOF社区之外的大量关注。最值得注意的是最近一篇关于经由PSM使用M0F作为固态催化剂的论文（Angew. 2009），其在催化学科中已经引起了相当大的关注。该提案还包括一项新的更广泛的影响/教学活动，以发展科学政策方面的实习和课程。位于华盛顿特区的加州大学中心（称为华盛顿特区的加州大学）正在创建一个科学政策暑期项目。PI是这个新项目的负责人，该项目涉及物理，生物，数学和工程科学学生在公共政策中科学的重要性的培训。除了课程和科学政策实习外，该方案还将包括研讨会、图尔斯参观等特别活动。这一创新计划将影响整个加州系统的学生，并有助于创造一代科学家谁更好地欣赏他们在社会和政府中的作用。

The Chemical Catalysis Program supports Professor Seth M. Cohen at the University of California- San Diego for a research project that will use post-synthetic modification (PSM) to alter metal organic framework (MOF) materials to introduce a range of functionalities without disrupting the overall structure and porosity of the MOFs. Post-synthetic modification is emerging as a useful tool to access functionalized MOFs that cannot be prepared directly. These materials will be useful as both homogeneous and heterogeneous catalysts. Although there are now quite a few examples of MOFs that have been used as heterogeneous catalysts, the proposal correctly identifies catalysis as an area of MOF chemistry that is under-developed. Preliminary studies show that chiral substituents, organocatalytic groups (carboxylic acids, ureas), and metal-binding groups can be readily introduced into MOFs by PSM. Early studies show that these modified MOFs are useful for catalytic reactions.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Cohen will perform research that contributes to metal-organic frameworks (MOFs) becoming more widespread as a material of choice for energy, catalysis, and biomedical applications. Based on these technological applications, and because of the growing importance of postsynthetic modification (PSM) of MOFs, Professor Cohen's work has garnered substantial attention from outside the immediate MOF community. Most notably is a recent paper on the use of MOFs as solid-state catalysts via PSM (Angew. Chem. 2009) that has gathered substantial attention in the catalysis discipline. This proposal also includes a novel broader impacts/teaching activity to develop internships and coursework in science policy. A Science Policy Summer Program at the University of California Center in Washington D.C. (called UC in DC) is being created. The PI is the Director of this new program that involves training of physical, biological, mathematical, and engineering science students in the importance of science in public policy. The program will involve special activities such as seminars, tours, in addition to coursework and science policy internships. This innovative program will impact students across the University of California system, and help to create a generation of scientists who better appreciate their role in society and in government.