GOALI: Organocatalytic Polymerization: New Synthetic Methods for Polymer Chemistry

化学催化项目支持斯坦福大学的Robert M. Waymouth教授和IBM的James L . Hedrick博士的一个研究项目，该项目将探索用于可控聚合反应的有机催化剂的新反应模式。具体目标是：(1)为有机催化聚合反应开发新的双功能策略；(2)深入了解两性离子聚合合成大环聚合物的动力学和机理；(3)开发新的有机催化方法合成可生物降解和生物相容性的聚磷酸盐。n -杂环碳烯介导的两性离子聚合是单体与高分子量环状聚合物链结的新进展。对这些反应细节的机理和动力学见解将为这种新合成方法的范围、能力和局限性提供概念性和定量的图景。有机催化聚合策略为主要商品聚合物的合成和回收提供了一种环境友好的方法。对新的连接机制的机械见解将为新聚合物结构的产生创造新的机会，包括用于生物医学应用的新聚磷酸盐家族。在美国国家科学基金会化学分部化学催化项目的支持下，Waymouth和Hedrick将进行研究，为设计来自可再生资源的可生物降解聚合物提供新的催化策略。作为该计划的一部分，新的合成方法将为合成定义良好的聚合物结构提供新的策略。这些发展将有助于研究聚合物结构在性质和功能上的作用，这些问题对我们对化学的理解和大分子在现代技术中的应用至关重要。更广泛的影响包括将学生纳入一个特殊的培训环境，包括学术机构和工业实验室之间高度跨学科和协作的努力。私立学校在招募和指导代表性不足的少数民族和残疾学生方面发挥了积极作用。此外，IBM还为这项工作投入了大量资源，包括为一名博士后同事和来访的斯坦福学生提供实验室和办公空间、材料和用品、广泛使用IBM的设施和基础设施，以及为Hedrick博士提供25%的时间。

The Chemical Catalysis Program supports Professor Robert M. Waymouth at Stanford University and Dr. James L Hedrick at IBM for a research project that will explore new patterns of reactivity of organic catalysts for controlled polymerization reactions. Specific objectives are to: (1) develop novel bifunctional strategies for organocatalytic polymerization reactions; (2) develop a detailed kinetic and mechanistic understanding of zwitterionic polymerizations for the synthesis of macrocyclic polymers; and (3) develop new organocatalytic methods for the synthesis of biodegradable and biocompatible polyphosphates. The zwitterionic polymerization mediated by N-heterocyclic carbenes is a new conceptual advance for the enchainment of monomers to high molecular weight cyclic polymers. Mechanistic and kinetic insights on the details of these reactions will provide a conceptual and quantitative picture of the scope, power and limitations of this new synthetic method. Organocatalytic polymerization strategies provide an environmentally friendly approach for the synthesis and recycling of major commodity polymers. Mechanistic insights on new mechanisms of enchainment will create new opportunities for the generation of novel polymer architectures, including new families of polyphosphates for biomedical applications.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Drs. Waymouth and Hedrick will perform research that will provide new catalytic strategies for the design of biodegradable polymers derived from renewable resources. New synthetic methods developed as part of this program will enable new strategies for the synthesis of well-defined polymer architectures. These developments will enable studies of the role of polymer structure on properties and function, issues that are fundamental to our understanding of chemistry and to the application of macromolecules in modern technologies. Broader impacts include involving students in an exceptional training environment involving a highly interdisciplinary and collaborative effort between an academic institution and an industrial laboratory. The PIs have taken an active role in recruiting and mentoring underrepresented minorities and disabled students. In addition, IBM is committing significant resources to this effort, including laboratory and office space for a postdoctoral coworker and visiting Stanford students, materials and supplies, extensive access to IBM facilities and infrastructure as well as 25% of Dr. Hedrick's time.