MRI-R2: Acquisition of a Nanotom-Computed Tomography System for Revolutionizing Metallic Biomaterials Research, Education and Training

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。计算机断层扫描（CT）是从不同方向观察物体投影的3d重建。CT非破坏性地生成一个完整的样品3D模型，允许许多可能性进行分析：切片的非破坏性可视化（一个非常强大的方面），任意截面视图，伪颜色表示和孔隙分析。技术的进步导致了CT分辨率和精度的不断提高。在过去，基于同步辐射的微ct （SRìCT）一直是高分辨率技术的选择。纳米层析成像（nanoCT）是最近发展起来的一项技术，利用亚-ìm焦斑尺寸的x射线源产生200-300纳米的空间分辨率。纳米oct的应用范围很广，从低吸收的生物样品到高吸收的金属物体，如金属植入材料。根据研究结果，所提出的系统为未来扩展设计和纳入适当的附件提供了空间，以便在体内环境条件下对材料行为进行高分辨率的原位可视化。NCAT的NSF ERC-RMB的愿景是彻底改变金属生物材料和基础科学和技术，导致工程系统，将与人体接口，延长和提高生活质量，再加上发展一个充满活力的，多样化的劳动力，为多学科和全球的挑战和机遇做好准备。其使命是发挥生物/纳米工程的潜力，显著改善骨科、颅面和心血管疾病的治疗。目标是开发新的植入材料和可调节的生物可降解金属，它们可以生长和适应人体，并最终在不再需要时溶解。

0959511SankarThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Computed tomography (CT) is the 3D-reconstruction of projections of an object viewed from different directions. CT non-destructively generates a fully 3D model of samples that allows many possibilities for analysis: the non-destructive visualization of slices (a very powerful aspect), arbitrary sectional views, pseudo-color representations and pore analysis. Technological advances have led to progressive improvements in CT resolution and accuracy. In the past, synchrotron radiation-based microCT (SRìCT) has been the high resolution technique of choice. Nanotomography (nanoCT), a recently developed technique, exploits X-ray sources with sub-ìm focal spot size to yield spatial resolutions down to 200-300 nm. NanoCT enables a large range of applications ranging from low-absorbing biological samples to high-absorbing metal objects such as metallic implant materials. The proposed system provides room for future expansion to design and incorporate appropriate accessories for high-resolution in situ visualization of material behavior in in vivo environmental conditions, as dictated by research findings. The vision of NCAT's NSF ERC-RMB is to revolutionize metallic biomaterials and underlying sciences and technologies, leading to engineered systems that will interface with the human body to prolong and improve quality of life, coupled with the development of a vibrant, diverse workforce well-prepared for the multidisciplinary and global challenges and opportunities of the new millennium. The mission is to deliver on the potential of bio/nanoengineering to dramatically improve treatments for orthopedic, craniofacial and cardiovascular ailments. The goal is to develop new implant materials and tunable biodegradable metals that can grow and adapt to the human body and eventually dissolve when no longer needed.