Development of Synthetically Versatile C-H Activation Reactions

该项目将重点发展广泛使用的Pd和Cu催化的C-H活化/三氟甲基化和C-H活化/卤化反应（包括氢化）。 尽管最近在这方面取得了进展，使用经典的环化，发现类似的反应性与合成有用的底物含有弱配位官能团仍然是一个重大的挑战。 将进行广泛的实验工作，以找到解决这些问题的基础上得到充分支持的假设。 此外，从研究中获得的知识将用于建立新的催化转化和探索潜在的反应机理，以开发对映选择性的C-H卤化反应。有了这个奖项，化学合成计划将支持斯克里普斯研究所化学系的Jin-Quan Yu教授的研究。 余教授的研究工作主要集中在发现和开发合成通用的C-H官能化反应。 这些转化代表了环境友好的化学合成方法，因为它们可以大大缩短合成序列。 基于这些反应的新技术可能对制药和农业化学工业的合成规划和直接实际应用产生重大影响。 此外，该项目还将为研究生和博士后提供优质的培训。 它还包括对高中生的外联活动。

This project will focus on the development of broadly useful Pd- and Cu-catalyzed C-H activation/trifluoromethylation and C-H activation/halogenation reactions (including fluorination). Despite recent progress on this front using classic cyclometalation, the discovery of analogous reactivity with synthetically useful substrates containing weakly coordinating functional groups remains a significant challenge. Extensive experimental work will be performed to find solutions to such problems based upon well supported hypotheses. In addition, the knowledge learned from the studies to establish new catalytic transformations and to probe the underlying reaction mechanisms will be applied to develop enantioselective C-H halogenation reactions.With this award, the Chemical Synthesis program is supporting the research of Professor Jin-Quan Yu of the Department of Chemistry at The Scripps Research Institute. Professor Yu's research efforts focus on the discovery and development of synthetically versatile C-H functionalization reactions. These transformations represent environmentally benign methods for chemical synthesis in that they may drastically shorten synthetic sequences. New technologies based on these reactions could have a substantial impact on synthetic planning and immediate practical applications in the pharmaceutical and agrochemical industries. In addition, this project will provide excellent training to both graduate students and postdoctoral fellows. It also involves outreach activities to high school students.