SBIR Phase I: Deformable Mirror Devices for Ocular Adaptive Optics

这个小型企业创新研究（SBIR）第一阶段项目旨在开发一种创新的微镜技术，以解决当前眼自适应光学（AO）面临的技术问题，包括无法校正高阶像差，像素之间的大串扰，在实现驱动器电子设备时体积庞大，以及过高的成本，使得反射镜不能集成到商业眼科仪器中，例如眼底照相机、共焦扫描激光检眼镜和光学相干断层扫描系统。第一阶段的项目将集中于建立一个实验室原型，以展示具有与眼睛瞳孔匹配的孔径尺寸的设备的概念验证波前校正，镜面表面图形的性能测试，操作速度，功耗，其材料系统的可靠性和稳定性，并进一步探索未来将反射镜架构单片集成到智能和低功率专用集成电路上的关键制造挑战（该项目的更广泛的影响/商业潜力是一种破坏性的微镜技术，其通过将成像分辨率提高到高达一个数量级、减小镜模块的尺寸和重量，使得能够将自适应光学器件实施到商业眼科仪器中。（包括相关接口板）高达两个数量级，因此变得像数码相机一样紧凑，以及通过以可接受的价格向仪器制造商提供眼睛临床AO模块。能够增强视网膜成像分辨率并将精确的激光光斑递送到视网膜的自适应光学系统在临床上能够解决包括视网膜脱离、黄斑变性和糖尿病性视网膜病变的几种眼部疾病。AO反射镜的其他市场应用包括生物医学显微镜、高分辨率成像和通过大气湍流的通信、激光束转向和光路对准。所提出的反射镜技术可以进一步适用于生产各种各样的扫描反射镜，用于微型投影仪显示器、血管内成像和光谱仪市场部门。

This Small Business Innovation Research (SBIR) Phase I project aims to develop an innovative micro mirror technology to address the technical problems facing the current ocular adaptive optics (AO) that include incapability to correct higher order aberrations, large cross-talk among pixels, being bulky and heavy in implementing driver electronics, and the prohibitively high cost that prevents mirror integration into commercial ophthalmic instruments such as fundus camera, confocal scanning laser ophthalmoscope, and optical coherence tomography systems. This Phase I project will focus upon building a laboratory prototype to demonstrate the proof-of-concept wavefront correction of the device having an aperture size matching that of an eye pupil, performance test of the mirror for surface figures, operational speed, power consumption, reliability and stability of its material system, and to further explore critical manufacturing challenges for future monolithically integration of the mirror architecture onto a smart and low-power application-specific integrated circuit (ASIC) substrate.The broader impact/commercial potential of this project is a disruptive micro mirror technology enabling implementation of adaptive optics into commercial ophthalmic instruments by improving imaging resolution to up to one order of magnitude, reducing size and weight of the mirror module (associating interface board included) up to two orders of magnitude, thus becoming as compact as a digital camera, and by offering the eye clinical AO module to instruments manufacturers at acceptable prices. An adaptive optics system capable of enhancing retinal imaging resolution and delivering an accurate laser spot to the retina could be clinically capable of addressing several ocular diseases including retinal detachment, macular degeneration, and diabetic retinopathy. Other market applications of the AO mirrors include biomedical microscope, high-resolution imaging and communication through atmospheric turbulence, laser beam steering, and optical path alignment. The proposed mirror technology could be further adapted to produce a wide variety of scanning mirrors for miniature projector displays, intravascular imaging, and spectrometer market sectors.