CAREER: Multiphysics Modeling and Experiments for Pulastile Membrane Sensors

这一职业建议的动机是目前缺乏动态监测支架动脉的机械状态的诊断工具，这种支架动脉通过手术植入以允许适当的心血管血流。将开发多物理模型并进行实验，以研究带有原位聚合物传感器的支架动脉的力学。这项研究的目标是发展：(1)用于评估大应变脉动膜传感器的三维多物理框架和(2)结构-传感器耦合模型，以预测传感器输出与动脉闭塞和僵化的不同阶段之间的相关性。拟议的工作有望弥合血管机械反应与血管健康现状之间的差距，并量化跳跃现场健康监测能力，使临床医生能够通过多功能传感器进行关键干预。

This CAREER proposal is motivated by the current lack of diagnostic tools to dynamically monitor the mechanical state of the stented artery that is surgically implanted to allow proper cardiovascular flow. Multiphysics models will be developed and experiments carried out to study the mechanics of a stented artery with an in situ polymer sensor. The research effort is targeted towards development of: (1) a 3-D multiphysics framework for evaluating large strain pulsatile membrane sensors and (2) a coupled structure-sensor model to predict the correlation between sensor output and the varying stage of artery occlusion and rigidification.The proposed work is anticipated to bridge the gap between vascular mechanical response and the current state of vascular health, and quantum jump the in situ health monitoring capability to enable critical clinician intervention through multifunctional sensors.