Engineering Rapid and Ultrasensitive Microsystem with Hybrid Nanomaterials

该项目的目标是设计一种快速和超灵敏的微系统，该微系统具有有效的预富集功能，并且使用磁性纳米颗粒进行快速和超灵敏的检测。本项目采用跨学科的方法研究纳米粒子增强预富集和检测，并将其与微流控装置集成。混合单元的微反应器概念将用于预测和表征分离效率，考虑到预选单元中的磁活性混合和输送。磁性纳米粒子将作为标记放大检测信号，用于小型化表面等离子体共振（SPR）检测。集成传感微系统在医学诊断、生物武器识别、食品安全和环境污染控制、基础生命科学研究等领域具有低成本、快速、手持的应用前景。从中学到研究生的综合研究和指导的分层架构将通过教师研究经验（RET）计划提高中学教师/学生对生物纳米技术的认识。它还将为招收和留住代表性不足的学生提供机会，重点是女学生。

The goal of this project is to engineer a rapid and ultrasensitive microsystem that has the function of efficient preconcentration, and rapid as well as ultrasensitive detection using magnetic nanoparticles. This project utilizes an interdisciplinary approach to study the nanoparticle-enhanced preconcentration and detection, and its integration to the microfluidic device. Microreactor concept for the mixing unit will be used to predict and characterize the seperation efficiency, considering the magnetically active mixing and transport in the preconcentration unit. Magnetic nanoparticle will be used as label to amplify detection signal for miniaturizable Surface Plasmon Resonance (SPR) detection.The integrated sensing microsystem has the prospect of producing low-cost, rapid, and hand-held devices for the practice of diagnostic medicine, the identification of biological weapons, the control of food safety and environmental pollutions, and basic life sciences research. The layered architecture of integrated research and mentoring for a continuum of students from middle school to graduate students will advance awareness of bionanotechnology to middle school teachers/students through Research Experience for Teachers (RET) program. It will also provide opportunities to recruit and retain underrepresented students, with a focus on female students.