Modular Photoassisted Diversity-Oriented Synthesis

国家科学基金会化学部的化学结构、动力学和机理计划支持丹佛大学的安德烈·库特拉泽教授开发新的一锅光解草胺合成反应。这项工作的目标是利用这种类型的光化学反应进行所谓的“面向多样性的合成”，或DOS。这种方法的多功能性和通用性将使库塔特拉泽博士的团队能够获得迄今为止无法获得的碳骨架，从而产生新的有机分子，可以快速筛选出治疗活性。这项工作还将涉及一种利用核磁共振光谱快速确定结构的创新方法。这项研究的广泛影响包括为学生提供从有机合成到光化学和光物理的多学科培训机会。合成分子在生物学和医学上的潜在应用包括以更快的速度发现新药。本科生将全年参与这项研究，库塔特拉泽博士正在做出重大努力，吸引来自代表性不足群体的学生来到他的实验室。

The Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation supports Professor Andre Kutateladze of the University of Denver, for the development of new one-pot photo-protolytic oxametathesis reactions. The goal of this work is to use this type of photochemical reaction for what is known as "diversity-oriented synthesis," or DOS. The versatility and generality of this methodology will allow Dr. Kutateladze's group to access heretofore inaccessible carbon skeletons, giving rise to new organic molecules that can be rapidly screened for therapeutic activity. The work will also involve an innovative new method for rapid structure determination by NMR spectroscopy.Broader impacts of the research include the multidisciplinary training opportunities for students, from organic synthesis to photochemistry and photophysics. Potential applications for the synthesized molecules in biology and medicine include new drug discovery at more rapid pace. Undergraduate participation in this research will be year-round, and Dr. Kutateladze is making a significant effort to attract students from underrepresented groups to his laboratory.