MRI: Development of Multifunctional CARS (Coherent Anti-Stokes Raman Spectroscopy) Imaging System

该主要研究仪器（MRI）奖的目标是开发一种多功能的相干反斯托克斯拉曼光谱（CARS）成像系统，该系统将能够对纳米科学、生物学和医学研究进行非破坏性和非侵入性测量，具有3D共聚焦和纳米级分辨率。该项目将在单个系统中集成形貌表征、基于微尺度CARS的多模态非线性光学成像和尖端增强的CARS成像能力。可交付成果包括多功能CARS系统、研究成果文档和工程学生教育。如果成功，该项目的成果将在一个核心设施中创建一个关键设备，作为该地区跨学科和多组织的研究和教育平台。该工具将支持面向不同人群的研究生和本科生教育，包括妇女和代表性不足的少数民族学生。该仪器的成功开发将为美国纳米科学/技术、材料科学、细胞生物学等领域的研究开辟许多机会。研究生和本科生将受益于参与研究和课堂教学。K-12学生和教师的参与也将在大学和K-12学校之间建立新的伙伴关系。

The objective of this Major Research Instrumentation (MRI) award is to develop a versatile, multifunctional coherent anti-Stokes Raman spectroscopy (CARS) imaging system that will be capable of nondestructive and noninvasive measurement for nanoscience, biology, and medical research with 3D confocality and nanoscale resolutions. The project will integrate morphology characterization, microscale CARS-based multimodal nonlinear optical imaging and tip-enhanced CARS imaging capabilities in a single system. Deliverables include a multi-functional CARS system, documentation of research results, and engineering student education.If successful, the results of this project will create a key equipment in a core facility that serves as a cross-disciplinary and multi-organization research and education platform in the region. The instrument will support education for graduate and undergraduate students for a diverse group of people, including women and underrepresented minority students. The successful development of this instrument will open many research opportunities in nanoscience/technology, material science, cellular biology and other fields in the United States. Graduate and undergraduate students will benefit through involvement in the research and classroom instruction. The engagement of K-12 students and teachers in this project will also establish new partnerships between the University and K-12 schools.