New nano-sculptured thin film structures for biosensing applications

德国莱比锡大学、以色列BGU大学和巴勒斯坦圣城大学的这一三方提案涉及环境和医疗传感的纳米技术解决方案。需要对水中的污染物、血液和其他体液中的毒素和病原体进行快速感应。这个问题现在是并将永远是全世界持续关注的问题。为了有效地解决这个问题，将使用一类称为雕刻薄膜（stf）的纳米材料和一种利用表面增强光学现象的传感技术。stf具有柱状形态，由各种形状的纳米柱组成，由1-3纳米的簇组成。它们的孔隙度允许液体渗透以及功能化以针对特定分析物（毒素等）。不同材料的stf将在lOM上设计和制造，使用热蒸发和电子束蒸发方法，在玻片和硅片上。这些载玻片可以采用纳米光刻技术来推广芯片实验室的概念。用于stf的材料包括金属或被金属薄涂层的电介质。在对stf的形貌和平面波反射/透射光谱进行lOM评估后，将在BGU和Al-Quds进行评估，作为利用表面增强拉曼散射、荧光、表面等离子体共振和局部表面等离子体共振的平台。然后将建立基于这些现象的传感器，这将需要其表面的功能化以及用于特定目标检测的生物受体偶联。

Nanotechnological solutions for environmental and medical sensing are addressed in this trilateral proposal by the lOM Leipzig Germany, BGU Israel and Al-Quds University Palestine. There is a need for rapid sensing of pollutants in water, toxins and pathogens in blood and in other body liquids. This problem Is and shall always remain an ongoing concern worldwide. In order to effectively address the problem, a class of nanomaterials will be used called sculptured thin films (STFs) and a sensing technique to exploit surface-enhanced optical phenomena. STFs have a columnar morphology comprising nano-columns of various shapes and made of 1-3 nm clusters. Their porosity allows infiltration by a liquid as well as functionalization to target specific analytes (toxins, etc.). STFs of different materials will be designed and fabricated at the lOM, using thermal evaporation and electronbeam evaporation methods, on glass slides and silicon wafers. The slides could be nanolithographically patterned to promote the lab-on-a-chip concept. The materials for STFs Include metals or dielectrics that are coated thinly with a metal. After evaluation at the lOM of their morphology and planewave reflection/transmission spectra, STFs will be evaluated at BGU and Al-Quds as platforms to exploit surface-enhanced Raman scattering, fluorescence, surface-plasmon resonance, and local surface-plasmon resonance. Sensors based on these phenomena will then be built which will require functionalization of their surfaces as well as bioreceptor conjugation for specific target detection.