Mosquito-borne viruses - how they cause disease and novel approaches to prevention

在澳大利亚，罗斯河病毒(RRV)是最常见的影响人类健康的昆虫传播病毒。1993至2008年间，确诊的RRV病例超过6万例。虽然这种疾病不是致命的，但它导致了严重的发病率，给个人、他们的家庭和社区带来了社会和经济代价。这个项目有几个全国性的好处。它将阐明RRV毒株是否与疾病的严重性有关，以及是否有人为因素影响症状的严重性。对这两方面的了解可以为制定预防和治疗战略提供新的途径。

In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. This project has several national benefits. It will elucidate whether there is an association between RRV strain and the severity of disease and if there are human factors that affect the seriousness of symptoms. Knowledge of both of these could provide new avenues for the design of prevention and treatment strategies.