Pan-Pacific Advanced Studies Institute. Genomic Applications to Marine Science and Resource Management in SE Asia

标题：泛太平洋高级研究院。基因组在东南亚海洋科学和资源管理中的应用下一代测序(NGS)的新兴领域正在扩大尖端科学基因组研究的能力，其应用可以改善自然资源的可持续管理。这个高级研究所将汇集太平洋两岸的顶尖科学家，了解新兴的NGS领域对东南亚海洋科学和资源管理的潜力。它的目的是建立在传统的桑格测序方法所获得的知识的基础上，这些方法正在开始识别东南亚地区海洋种群结构的确证模式。这些模式检验了关于该区域高度海洋生物多样性的生态和进化起源的假设，并为如何保护和可持续管理这些资源提供了指导方针。先进基因组学已显示出极大地加强这一研究领域的潜力。与会者将来自东南亚和美国，发表演讲，指导计算机教程，并听取下一代分子生态学专家的意见，重点是海洋生态、保护遗传学和资源管理。该研究所将侧重于六个主要主题：a)自然种群的遗传多样性、系统地理和在东南亚海洋管理中的应用；b)当地适应的遗传学；c)自然选择的基因组特征；d)基于全球基因表达谱的功能生态学；e)海洋和养护科学的限制性位点相关DNA测序方法；f)种群生态学中的单核苷酸多态与微卫星。综合研讨会将推荐一项将NGS应用于东南亚海洋科学和资源管理的计划。该研究所的成功将为今后跨越太平洋盆地的讲习班铺平道路。它将展示如何促进美国和东南亚科学家之间的合作研究基地，这种更广泛的影响将与正在进行的国家科学基金会支持的珊瑚三角帝国项目启动的研究和教育的总体目标协同工作。该研究所将直接扩大珊瑚三角帝国项目的目标，即培训一批专注于东南亚的新的国际青年科学家，并建立长期的研究合作。该研究所将帮助消除美国研究人员在东南亚国家的障碍，同时促进将尖端和强大的分子生态学方法转移到这些国家的新兴研究团队和机构。这种交流将使发展中国家能够迅速从这些进步中受益，这些进步将有助于保护濒危的粮食储备和生物多样性中心。

Title: Pan-Pacific Advanced Studies Institute. Genomic Applications to Marine Science and Resource Management in Southeast AsiaAbstract The emerging field of Next Generation Sequencing (NGS) is expanding capabilities for cutting-edge scientific genomic research, with applications that can improve sustainable management of natural resources. This Advanced Study Institute will draw together leading scientists from both sides of the Pacific to understand the potential of the emerging field of NGS to marine science and resource management in Southeast Asia. It aims to build on the knowledge gained by traditional Sanger sequencing methods that are beginning to identify corroborated patterns of marine population structure in the Southeast Asian region. These patterns test hypotheses about the ecological and evolutionary origins of the high marine biodiversity in the region and provide guidelines on how to protect and sustainably manage these resources. Advanced genomics has demonstrated potential to greatly enhance this line of research. Participants will come together from Southeast Asia and the United States to present lectures, guide computer tutorials, and hear from experts in next generation molecular ecology with an emphasis on marine ecology, conservation genetics, and resource management. The institute will focus on six main topics: a) Genetic diversity in natural populations, phylogeography, and applications to marine management in Southeast Asia; b) Genetics of local adaptation; c) Genomic signatures of natural selection; d) Functional ecology based on global gene expression profiling; e) Restriction-site Associated DNA sequencing (RAD-seq) approaches to marine and conservation sciences; and f) Single Nucleotide Polymorphisms versus microsatellites in population ecology. Synthesis workshops will recommend a program of NGS applications to marine science and resource management in Southeast Asia. The success of this institute will pave the way for future workshops spanning the Pacific basin. It will demonstrate how a collaborative research base can be catalyzed between scientists in the United States and Southeast Asia This broader impact will work synergistically with the overarching goals of research and education started by the ongoing National Science Foundation -supported Coral Triangle-PIRE project. The Coral Triangle-PIRE project objectives of training a new international cohort of young scientists focused on Southeast Asia and of establishing long-lasting research collaborations will be directly amplified by this institute. The institute will help to dissolve barriers for United States researchers in Southeast Asian countries, while facilitating the transfer of cutting-edge and powerful molecular ecology methodologies to emerging research teams and institutes in these countries. Such exchanges will allow developing nations to benefit rapidly from these advances that will help preserve imperiled food stocks and centers of biodiversity.