MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis

有了这项由化学催化计划共同资助的主要研究仪器（MRI）计划的奖项，来自特拉华州大学的Charles Riordan教授及其同事Donald沃森和Joel Rosenthal将获得高分辨率质谱仪（HRMS）。该提案旨在加强各级的研究培训和教育，特别是在以下领域：（a）反应发现和表面图案化;（B）先天免疫系统的细菌激活;（c）微生物能量代谢;（d）生物质衍生化学中间体的催化升级;（e）镍氧化学;（f）太阳能燃料和可再生能源;（g）低价铬络合物的制备、反应性和催化活性;（h）过渡金属催化反应的发展;及（i）镍-及铜-缩醛和羧酸盐的催化反应。高分辨率质谱仪通过从样品中产生离子来分析样品，这些离子被注入到质谱仪中，它们的质/荷比被高精度地测量。 所获得的质量信息提供关于样品的化学组成的定性和定量信息。 该仪器使用各种工具来注入样品并进行分析，这将允许分析从液体到固体的各种小分子。该奖项提供的仪器将为几个部门的教师和学生提供使用最先进仪器进行研究项目的机会。它也将被用于几个实验室课程，培训本科生在使用这个广泛使用的分析工具。 特拉华州大学的质谱仪设施将与该地区的一些机构合作并共享仪器，包括特拉华州州立大学、林肯大学、华盛顿大学、布林莫尔学院和德雷克塞尔大学。

With this award from the Major Research Instrumentation (MRI) Program that is also co-funded by the Chemical Catalysis Program, Professor Charles Riordan from the University of Delaware and colleagues Donald Watson and Joel Rosenthal will acquire a high-resolution mass spectrometer (HRMS). The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) reaction discovery and surface patterning; (b) bacterial activation of the innate immune system; (c) microbial energy metabolism; (d) catalytic upgrading of biomass-derived chemical intermediates;(e) nickel-oxygen chemistry; (f) solar fuels and renewable energy; (g) preparation, reactivity, and catalytic activity of low-valent chromium complexes; (h) development of transition metal catalyzed reactions; and (i) nickel- and copper-catalyzed reactions of acetals and carboxylates.A high resolution mass spectrometer analyzes samples by creating ions from it which are injected into the spectrometer where their mass/charge ratios are measured to high accuracy. The mass information that is obtained provides qualitative and quantitative information on the chemical composition of the sample. This instrument uses a variety of tools to inject the sample and ionize it, which will allow a broad range of small molecules to be analyzed from liquids to solids. The instrumentation provided by this award will provide faculty and students in several departments the opportunity to pursue research projects using state-of-the-art instrumentation. It will also be used in several laboratory courses to train undergraduate students in the use of this widely employed analytical tool. The mass spectrometer facility at the university of Delaware will partner and share the instrument with a number of institutions in the region including, Delaware State University, Lincoln University, Washington University, Bryn Mawr College and Drexel University.