MRI: Acquisition of NMR spectroscopic instrumentation at Syracuse University

在主要研究仪器（MRI）的这一奖项和化学研究仪器和设施（CRIF）计划的支持下，来自锡拉丘兹大学的Karin Ruhlandt-Senge教授及其同事Philip Borer将获得一台带有液氮冷却探头的高度自动化400 MHz NMR光谱仪。该提案旨在加强各级的研究培训和教育，特别是在以下领域：（a）高活性金属物质的反应性、弱相互作用和聚集;（B）开发用于靶向药物输送的多糖载体;（c）核酸开关;（d）SHIP-磷酸酶抑制剂;（e）用于复杂分子合成的手性催化剂;（f）金属离子在生物学和医学中的作用;（g）生物活性肽和肽传感器;（h）具有独特折叠的非天然分子;（i）量子点界面处的动态配体交换;（j）2-亚甲基四氢吡喃的碳-碳键形成反应;和（k）锝和锝基放射性药物。核磁共振（NMR）光谱是化学家可用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。许多与该应用相关的研究项目将对社会产生直接影响，因为它们旨在开发仿生聚合引发剂，传感器，导电材料，以及新药或治疗方法，疫苗等。该仪器将成为锡拉丘兹大学和邻近机构教学和研究的组成部分。

With this award from the Major Research Instrumentation (MRI) and support from the Chemistry Research Instrumentation and Facilities (CRIF) Programs Professor Karin Ruhlandt-Senge from Syracuse University and colleague Philip Borer will acquire a highly automated 400 MHz NMR spectrometer with a liquid-nitrogen cooled probe. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) reactivity, weak interactions, and aggregation in highly reactive metal species; (b) development of polysaccharide-based carriers for targeted drug delivery; (c) nucleic acid switches; (d) inhibitors of SHIP-phosphatase; (e) chiral catalysts for use in complex molecule synthesis; (f) role of metal ions in biology and medicine; (g) bioactive peptides and peptide sensors; (h) unnatural molecules with unique folds; (i) dynamic ligand exchange at quantum dot interfaces; (j) carbon-carbon bond forming reaction of 2-methylenetetrahydropyrans; and (k) technetium and rhenium-based radiopharmaceuticals.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. Many research projects associated with this application will have a direct impact on society, as they aim to develop biomimetic polymerization initiators, sensors, conducting materials, and new drugs or treatments, vaccines, amongst others. This instrument will be an integral part of teaching as well as research at Syracuse University and also at neighboring institutions.