MRI: Development of a Near-Real-Time High-Accuracy Musculoskeletal System Measurement and Analysis Instrument (SKELETALMI)

该项目开发了一种名为SKELETALMI的近实时高精度肌肉骨骼系统分析仪器，旨在能够及时和准确地测量、分析和表征体内组合的关节运动、全身运动学、骨骼肌活动和身体反作用力。该仪器由硬件部件组成，包括用于获取透视X射线图像的设备、用于测量全身运动的设备、用于骨骼肌肉活动的设备、用于测量下半身和上半身反作用力的设备、以及一个高性能计算机系统；以及用于联合分析和描述活体关节运动学、关节动力学和肌肉激活的软件。SKELETALMI预计将--通过荧光图像和光学图像之间的重叠实现实时校准；--从CT和MRI扫描中实时地自动重建3D骨骼模型；--通过2D/3D配准，自动估计3D活体骨骼运动；-自动建立3D骨骼协调系统，将3D活体运动转换为3D关节运动学；-融合准确的关节运动学、全身运动学、肌肉激活和身体反作用力，并将数字人体模型上的所有信息可视化。这一发展具有强大的多学科组成部分，涉及算法、生物力学、生物医学成像、人机界面和计算机图形学。该项目是罗格斯大学与新泽西州立大学和凯斯勒基金会研究中心的联合努力。广泛的影响：该仪器影响到许多应用领域，如鞋子设计、运动训练、伤害预防、衰老、与运动相关的医疗器械的设计，以及手术/康复技术创新。在仪器能力和收集的新相关数据的支持下，将开发肌肉骨骼生物力学、图形模拟、运动分析和生物医学图像分析的新课程。因此，该仪器还影响该机构的教育计划，这些计划应该培养出具有计算科学、医学科学和产品设计综合知识的毕业生。

This project, developing an instrument for near-real-time high-accuracy musculoskeletal system analysis named SKELETALMI, aims to enable timely and accurate measurement, analysis, and characterization of in vivo combined joint movement, whole body kinematics, skeletal muscle activity, and body reaction forces. The instrument consist of hardware components that include devices for fluoroscopic X-ray image acquisition, for measuring whole body movement, for skeletal muscle activity, for measuring lower and upper body reaction forces, and a high performance computer system; as well as software to analyze and characterize jointly in vivo joint kinematics, joint kinetics, and muscle activation.SKELETALMI is expected to - Allow real-time calibration through overlay between fluoroscopic images and optical images;- Automatically reconstruct 3D bone models from CT and MRI scans in real-time;- Automatically estimate 3D in vivo bone movement through 2D/3D registration; - Automatically establish 3D bone coordinated systems and convert the 3D in vivo movement into 3D joint kinematics;- Fuse the accurate joint kinematics, whole body kinematics, muscle activation, and body reaction forces and visualize all the information on digital human models.This development has a strong multidisciplinary component that involves algorithms, biomechanics, biomedical imaging, HCI, and computer graphics. The project constitutes a joint collaborative effort of Rutgers with the State University of NJ and Kessler Foundation Research Center.Broader Impacts: The instrumentation impacts many application domains such as shoe design, athletic training, injury prevention, aging, design of movement-related medical device, and surgical/rehabilitation technique innovation. Underpinned by the capabilities of the instrument and the new related data collected, new courses will be developed in musculoskeletal biomechanics, graphics simulation, movement analysis, and biomedical image analysis. Consequently, the instrument also influences the educational programs at the institution that should generate graduates with a comprehensive knowledge of computational sciences, medical science, and product design.