Conference: FASEB Summer Research Conference on Mitosis: Spindle Assembly and Function conference being held August 5-10, 2012 in Steamboat Springs, Colorado.

目的：细胞分裂（有丝分裂）是细胞周期的顶点，即使是控制有丝分裂的分子机制中看似微小的缺陷也会深刻影响子细胞的命运，并最终影响整个生物体的命运。因此，阐明细胞分裂的基本机制一直是细胞生物学的焦点，因为这个动态和复杂的过程是由早期显微镜揭示。大量的科学家研究有丝分裂器组装和功能的各个方面。事实上，有丝分裂领域融合了分子细胞生物学、生物化学、生物物理学、计算生物学和功能基因组学。为了促进信息和思想的交流，以及鼓励新的跨学科合作，要求基金为年轻科学家提供NSF旅行奖（研究生、博士后和初级教师）参加FASEB主办的有丝分裂会议：纺锤体组装和功能。这次国际会议由印第安纳州大学的克莱尔·沃尔扎克教授组织，（布卢明顿，印第安纳州，美国）和Erich Nigg的Biozentrum，巴塞尔大学（巴塞尔，瑞士），将汇集约175名研究人员从不同的分支学科在有丝分裂领域。会议的总体目标是鼓励研究有丝分裂各个方面的科学家之间直接交流思想和实验数据。沃兹沃斯中心（纽约州奥尔巴尼）的著名科学家Conly里德尔博士将在会议上作主旨发言。他的演讲将集中在细胞分裂的理解概念的发展，它将把最近公布的分子机制的活细胞显微镜观察的背景下，在几十年的过程中。讲台演讲将邀请国际知名专家，以及年轻的科学家（研究生，博士后和初级教师），他们的工作将从提交的摘要中选出。九个平台部分涵盖有丝分裂的所有主要方面将举行：1。有丝分裂纺锤体组装; 2.有丝分裂的定量方法; 3.中心体的结构和功能; 4.动粒组装和功能; 5.染色体结构与功能; 6.有丝分裂职业研讨会; 7.胞质分裂和有丝分裂退出; 8.染色体分离和非整倍性; 9.有丝分裂在发展中特别值得注意的是有丝分裂职业研讨会，在该领域的三位高级领导人（教授迪克麦金托什，玛丽安乔丹和特德鲑鱼）将提供他们对这一领域的许多贡献的概述。此外，关于有丝分裂定量方法的会议代表了对该领域未来至关重要的最新多学科科学，而关于有丝分裂发展的会议旨在将细胞生物学与有丝分裂整合在更广泛的有机体背景下。为了补充平台会议，将分配时间举行三次海报会议，每次2小时。下午的其余时间将安排非正式的科学交流，以促进跨学科的互动，并促进新的合作的启动。更广泛的影响：会议的一个独特之处是，它将侧重于传播新的前沿信息，在教学和专业吸收的形式，这是在有丝分裂研究的快速变化的科学景观至关重要。由于专业文献数量巨大且种类繁多，特别是对于最近才进入该领域的年轻科学家来说，很难从共同的角度看待个人发现。此外，由于会议的规模较小和非正式性质，这个地点为年轻科学家提供了一个独特的机会，与该领域的世界知名专家进行互动，以获得他们对研究的见解和观点。研究生，博士后研究员和初级教师都将被考虑为平台演示文稿，以展示他们的工作，所有与会者都将在平台或海报会议上展示研究，以确保每个人都积极参与会议。从这次会议上收集的信息将用于通过向积极参与世界各地机构的研究生和本科生培训和教育的与会者广泛传播最新信息来推进与会者的研究和教育目标。

Objectives: Cell division (mitosis) is the culmination of the cell cycle, and even seemingly minute deficiencies in the molecular mechanisms that control mitosis profoundly affect the fate of the daughter cells and ultimately, the fate of the entire organism. As such, elucidating the fundamental mechanisms of cell division has been in the focus of cell biology ever since this dynamic and complex process was revealed by early microscopy. A vast number of scientists investigate various aspects of the mitotic apparatus assembly and function. In fact, the field of mitosis amalgamates molecular cell biology, biochemistry, biophysics, computational biology, and functional genomics. To foster exchange of the information and ideas, as well as to encourage new interdisciplinary collaborations funds are requested to provide NSF travel awards for young scientists (graduate students, post-docs, and junior faculty) to attend the FASEB sponsored meeting on Mitosis: Spindle Assembly and Function.Intellectual Merit: This international meeting, organized by professors Claire Walczak of Indiana University (Bloomington, Indiana, USA) and Erich Nigg of Biozentrum, University of Basel (Basel, Switzerland), will bring together approximately 175 researchers from the various subdisciplines within the field of mitosis. The overall aim of the meeting is to encourage direct exchange of ideas and experimental data among scientists who study diverse aspects of mitosis. The meeting will feature a keynote address by the eminent scientist Dr. Conly Rieder of the Wadsworth Center (Albany, NY). His lecture will focus on conceptual developments in the understanding of cell division, and it will put recently-unveiled molecular mechanisms in the context of live-cell microscopy observations made over the course of several decades. Podium presentations will feature invited internationally-renowned experts, as well as younger scientists (graduate students, post-docs, and junior faculty) whose work will be selected from the submitted abstracts. Nine platform sections covering all major aspects of mitosis will be held: 1. Mitotic spindle assembly; 2. Quantitative approaches to mitosis; 3. Centrosome structure and function; 4. Kinetochore assembly and function; 5. Chromosome structure and function; 6. Mitosis career symposium; 7. Cytokinesis and mitotic exit; 8. Chromosome segregation and aneuploidy; 9. Mitosis in Development. Of special note is the Mitosis Career Symposium in which three senior leaders in the field (Professors Dick McIntosh, MaryAnn Jordan, and Ted Salmon) will provide an overview of their many contributions to this field. In addition, the session on quantitative approaches to mitosis represents the newest multidisciplinary science that is critical to the future of this field, and the session on mitosis in development is aimed to integrate the cell biology with mitosis in the broader context of the organism. To complement the platform sessions, time will be allocated for three poster sessions, each 2 hours long. The remainder of the afternoons will be orchestrated for informal scientific exchanges to promote cross-disciplinary interactions and to nurture the initiation of new collaborations.Broader Impacts: A unique feature of the meeting is that it will focus on disseminating new cutting-edge information in a didactic and expertly assimilated form, which is essential in the rapidly changing scientific landscape of research in mitosis. Due to enormously vast and diverse professional literature it has become difficult, particularly for younger scientists who only recently entered the field, to view individual discoveries in a common perspective. In addition, because of the small size and informal nature of the meeting, this venue provides a unique opportunity for young scientists to interact with world-renowned experts in the field to gain their insight and perspective on their research. Graduate students, post-doctoral fellows, and junior faculty will all be considered for platform presentations to feature their work, and all attendees are expected to present research in platform or poster sessions to ensure that everyone actively participates in the meeting. The information gathered from this meeting will be used to advance both the research and educational goals of the meeting participants by broadly disseminating the latest information to participants, who are actively involved in graduate and undergraduate training and education at institutions throughout the world.