Exploiting the Hydrodynamic Coupling Effect for Capture and Manipulation of Nanotextured Particles and Cells

表面非均质性在粒子与表面的粘附中起着重要作用，即使粒子和表面都均匀地带着相同的电荷符号——这应该使两个表面都具有很强的斥力。PI先前通过使用非均质收集表面来捕获非均质？颗粒具有很强的特异性和效率。当非均质性存在于流动的颗粒上而不是收集器上时，该建议将其重点转向非均质性（流动颗粒的非均质性驱动波动）的动态后果。拟议的工作将有助于扩大传感和分离技术的范围，超越对生物分子识别范式的依赖，从而能够创建能够承受广泛操作条件的分离和传感系统。PI将演示如何从他们的研究中获得的基本理解可以转化为3个特定应用：血液中的异质药物载体，在线细菌传感和非基于免疫的全细胞癌症诊断。

The role of surface heterogeneity can play a major role in particle adhesion to surfaces, even when both particle and surface are uniformly charged with the same sign of charge--which should make both surfaces strongly repulsive. The PI has previously demonstrated the magnitude of heterogeneity effect by using heterogeneous collecting surfaces to capture ?homogenous? particles with great specificity and efficiency. This proposal turns its focus on the dynamic consequences of heterogeneity (heterogeneity-driven fluctuations of flowing particles), when heterogeneity resides on the flowing particle rather than the collector. The proposed work will contribute to a broadening of sensing and separations technologies beyond reliance on the bio-molecular recognition paradigm to enable creation of separations and sensing systems that can withstand a broad range of operating conditions. The PI will demonstrate how the fundamental understanding derived from their studies can be translated to 3 specific applications: heterogeneous drug carriers in blood, on-line bacterial sensing, and a non-immuno-based whole-cell cancer diagnostic.