SST: Patchy Sensor Surfaces for Selective Dynamic Adhesion of Micron and SubMicron Objects

SST：用于微米和亚微米物体选择性动态粘附的片状传感器表面

• 批准号: 0428455
• 负责人: Maria Santore
• 金额: $ 71.55万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-11-01 至 2008-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0428455&HistoricalAwards=false
• 关键词: SST; Patchy; Sensor; Surfaces; Selective

AbstractProposal Number: CTS-0428455Principal Investigator: Maria M. SantoreInstitution: University of Massachusetts AmherstTitle: Patchy Sensor Surfaces for Selective Dynamic Adhesion of Micron and Submicron Objects Merit: This program will develop the science for robust field-ready sensors for particles with sizes from 50 nm to 5 um, applicable to the detection of bacteria, spores, viruses, inorganic fines, and chemically-sensitive scavenging particles from aqueous and airborne environments. Focusing on reversible dynamic adhesion as these objects flow over detector surfaces that spontaneously recover after a .detection event., the program targets a new sensing concept that will screen and discriminate classes of biological cells or inorganic particles based on their surfaces. This class-level selectivity will not require steps that lyze cells, extract proteins or genetic material, or conduct molecular recognition. Multiple applications are therefore targeted. At the heart of this new sensing technology lies a heterogeneous or patterned surface which is robust to pH, temperature, and other environmental factors, and which selectively adheres target particles while rejecting those outside target ranges in size or surface character (mean density or nanoscale distribution of surface charge, nano-meter scale patches of hydrophobic and hydrophilic chemistries, scale of roughness and other aspects of surface topography, and even specific peptide sequences). The sensor surfaces present nanometer-scale patches of different sizes and chemistries, and micron-scale hydrodynamic features that generate a landscape of competing colloidal and hydrodynamic forces to discriminate approaching colloidal particles based on their dynamic signature, including reversible adhesion, rolling, skipping, and arrest. The proposed collaboration between Santore, Coughlin, and Davis spans the disciplines of polymer interfaces, synthetic chemistry, and fluid mechanics. Through combined experiment and modeling, the team will develop design rules for collector surface patterns, robust detector chemistry, and operating strategies that manipulate concentration, ionic strength, and flow rates. With model particles capturing the essential features of spores, bacteria, viruses, resins, and minerals, the program will probe adhesion and detachment rates on patterned collector surfaces with systematic variations in the scale and chemistry of surface features. Surface features will be designed with particular colloidal forces (electrostatic, Van der Waals, hydrophobic, and polymer mechanical) and hydrodynamic fields in mind, exploiting the versatility of block copolymer architectures, and flow fields engineered to manipulate particle-surface encounters. Broader impacts. The new sensing technology will benefit society not only in terms of homeland security, but also in terms of public welfare: The sensing principles employ active surfaces which could be produced at modest cost, and designs which can operate unattended and automatically, in chemical processes and public buildings such as hospitals and schools, and ultimately the home. The program, while rooted in the interdisciplinary fields of nanochemistry and colloid science, impacts the fields of polymer surface chemistry, biophysics, and pattern recognition, and will initiate a surface fingerprinting database of single cell organisms. Graduate students will carry forward the bulk of the fundamental science while a liaison program will benefit engineering, chemistry, and physics undergraduates via a hybrid industrial / university research experience. Undergraduates will spend a summer in industry on a project with science parallel to that in the Santore / Davis/ and Coughlin labs, returning to UMass to conduct a related research project during the academic year. Integrated teaching and research will be accomplished with a special topics course on smart interfaces, and with guest lectures in key courses in the undergraduate curriculum of two UMass colleges. The program will target underrepresented groups by recruiting students from local colleges who take courses at UMass.

摘要提案编号：CTS-0428455主要研究者：Maria M. SantoreInstitution：马萨诸塞州阿默斯特大学题目：用于微米和亚微米物体选择性动态粘附的贴片传感器表面优点：该计划将开发用于颗粒尺寸从50 nm到5 um的强大现场就绪传感器的科学，适用于检测细菌，孢子，病毒，无机细颗粒和水和空气环境中的化学敏感清除颗粒。 关注这些物体流过检测器表面时的可逆动态粘附，这些物体在检测事件后自发恢复，该计划的目标是一种新的传感概念，将根据生物细胞或无机颗粒的表面筛选和区分它们的类别。这种类水平的选择性将不需要裂解细胞，提取蛋白质或遗传物质，或进行分子识别的步骤。因此，针对多个应用程序。 这种新的传感技术的核心在于异质或图案化的表面，其对pH、温度和其他环境因素是鲁棒的，并且其选择性地粘附目标颗粒，同时拒绝那些在尺寸或表面特性上超出目标范围的颗粒（表面电荷的平均密度或纳米级分布，疏水和亲水化学物质的纳米级斑块，粗糙度的尺度和表面形貌的其它方面，甚至特定的肽序列）。 传感器表面呈现不同尺寸和化学性质的纳米级补丁，以及微米级流体动力学特征，其产生竞争胶体和流体动力学力的景观，以基于其动态特征（包括可逆粘附、滚动、跳跃和逮捕）来区分接近的胶体颗粒。 Santore，Coughlin和Davis之间的拟议合作跨越了聚合物界面，合成化学和流体力学的学科。通过结合实验和建模，该团队将开发收集器表面图案的设计规则，强大的检测器化学，以及操纵浓度，离子强度和流速的操作策略。 随着模型颗粒捕捉孢子，细菌，病毒，树脂和矿物的基本特征，该计划将探测图案化的收集器表面上的粘附和分离率，表面特征的尺度和化学性质存在系统性变化。 表面特征的设计将考虑到特定的胶体力（静电力、货车德瓦尔斯力、疏水力和聚合物机械力）和流体动力学场，利用嵌段共聚物结构的多功能性，以及设计用于操纵颗粒-表面接触的流场。 更广泛的影响。 新的传感技术将不仅在国土安全方面造福社会，而且在公共福利方面也是如此：传感原理采用可以以适度成本生产的活性表面，以及可以在化学过程和公共建筑（如医院和学校）中无人值守和自动运行的设计，最终用于家庭。 该计划植根于纳米化学和胶体科学的跨学科领域，影响聚合物表面化学，生物物理学和模式识别领域，并将启动单细胞生物的表面指纹数据库。 研究生将推进大部分基础科学，而联络计划将通过混合工业/大学研究经验使工程，化学和物理本科生受益。 本科生将花一个夏天在工业上的一个项目与科学平行，在桑托/戴维斯/和考夫林实验室，返回马萨诸塞大学进行相关的研究项目在学年。 综合教学和研究将完成与智能接口的专题课程，并在两个麻省大学本科课程的重点课程客座讲座。 该计划将通过从当地大学招收在马萨诸塞大学学习课程的学生来瞄准代表性不足的群体。