Catalysis Chemistry Involving Nucleosides and Related Heterocycles

美国国家科学基金会化学部的化学催化项目为纽约城市学院和城市大学的Mahesh K. Lakshman教授的研究和教学活动提供支持。Lakshman教授的研究涉及使用催化方法对核苷和嘌呤衍生物以及密切相关的杂环进行化学修饰。研究了金属催化碳-碳和碳-氮成键方法。这项研究有几个目的：核苷的化学选择性和室温转化，设计新的配体来调节催化转化，开发苯并三唑核苷类似物，以及使用嘧啶、喹唑啉和嘌呤作为有机分子功能化的潜在一次性手柄。Lakshman教授与几个国家和国际机构的研究人员合作，以获取作为该项目一部分创建的新核苷和相关杂环的活性。这项研究具有不同程度的复杂性，所有教育水平的学生都参与了这项计划。此外，这项研究还带来了向当地学校和大学推广的机会。金属催化反应提供了一种最先进的方法来组装复杂的分子结构，这通常是其他方法无法实现的。核苷和嘌呤是重要的生物分子，在生物化学、生物学和医学等领域有着广泛的应用。金属催化的核苷和嘌呤反应允许这些生化支架的多样化，并提供了以前未知的分子结构。金属催化也提供了获得类似核苷的分子的途径，嘌呤和相关杂环的内在化学反应性可以以新的方式被潜在地利用。作为这项研究的一部分产生的新核苷和相关异质结构在几所药学院和医疗机构中被评估为潜在的抗病毒或抗艾滋病毒药物以及心血管疾病和癌症的治疗方法。不同教育水平的学生，包括来自当地的初高中和大学的学生，通过参与这个研究项目，获得了当代化学和专业准备方面的培训。

The Chemical Catalysis Program of the Chemistry Division at the National Science Foundation supports the research and pedagogical activities of Prof. Mahesh K. Lakshman at The City College and The City University of New York. Professor Lakshman's research involves the chemical modification of nucleosides and purine derivatives as well as closely related heterocycles, using catalysis methodology. Studies are conducted on metal-catalyzed carbon-carbon and carbon-nitrogen bond-formation methodologies. There are several aims of the research: chemoselective and room-temperature transformations of nucleosides, design of new ligands for modulation of catalytic conversions, development of benzotriazolyl nucleoside analogues, and use of pyrimidine, quinazoline, and purine as potentially disposable handles for functionalization of organic molecules. Professor Lakshman collaborates with researchers at several national and international institutions to access the activity of the new nucleosides and related heterocycles created as part of this project. The research has various levels of complexity and students at all educational levels participate in the program. In addition, this research has led to opportunities for outreach to local schools and colleges. Metal-catalyzed reactions offer a state-of-the-art approach to assembling complex molecular structures, often not accessible by other means. Nucleosides and purines are highly important biomolecules with applications in biochemistry, biology, and medicine. Metal-catalyzed reactions of nucleosides and purines allow for ready diversification of these biochemical scaffolds and provide access to previously unknown molecular architectures. Metal catalysis also offers access to molecules that resemble nucleosides, and the intrinsic chemical reactivity of purines and related heterocycles can potentially be exploited in new ways. New nucleosides and related heterostructures that are produced as part of this research are evaluated at several schools of pharmacy and medical institutions as potential anti-viral or anti-HIV medicines as well as treatments for cardiovascular disease and cancer. Students at various educational levels, including those from local middle and high schools and colleges, gain training in contemporary chemistry and professional preparation by participating in this research project.