Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

在这个由化学系化学合成计划资助的项目中，斯坦福大学化学系的保罗·A·温德教授和同事将探索用于有机合成的新反应、试剂和催化剂的开发。研究将集中在用于[5+2]环加成反应的新试剂和用于多组分[5+2]/[4+2]环加成反应的新的反应性传递试剂家族。研究还将针对碳-碳键活化的新策略，这是一大类环加成反应中的一个必要步骤。最后，研究将针对生物系统成像和传感的第一个传输器-催化剂偶联物的开发。这项研究旨在介绍用于有机合成的新反应、催化剂和试剂，从而介绍合成理论、药物、材料、成像和能源研究中感兴趣的分子的新策略。新的反应、催化剂和试剂改变了我们对键结构的看法，从而提供了改进步骤和时间经济性的选择，并提供了更环保的方法来制造具有科学和社会价值的分子。这些进展为制药、农业、精细化工、材料科学、环境科学和能源行业提供了基础，也为科学研究提供了基本工具。这项关于分子过程的工作的重点也提高了我们对分子结构和功能的基本知识，这反过来又为从分子人类学到分子动物学的科学的分子化提供了基础。这项研究为本科生、研究生和博士后研究员(包括来自历史上代表性不足的群体)提供了一个特殊的培训计划，并为其他人利用化学来解决医学、材料、诊断和能源研究中迫切和悬而未决的问题提供了灵感和知识的来源，这从300多名参加过该项目的前同事中可见一斑，其中许多人在学术界和工业界担任领导职务。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Paul A. Wender and co-workers of the Department of Chemistry at Stanford University will explore the development of new reactions, reagents and catalysts for organic synthesis. Studies will focus on new reagents for [5+2] cycloadditions and on a new family of reactivity relaying reagents for multicomponent [5+2]/[4+2] cycloadditions. Studies will also be directed at new strategies for carbon-carbon bond activation, a required step in a large class of cycloaddition reactions. Finally, studies will be directed at the development of the first transporter-catalyst conjugates for imaging and sensing in biological systems. This research is directed at the introduction of new reactions, catalysts and reagents for organic synthesis and thus at the introduction of new strategies for synthesizing molecules of interest for theoretical, medicinal, materials, imaging and energy research. New reactions, catalysts and reagents change how we think about bond construction, thereby providing options for improving step and time economy and providing greener if not ideal approaches to making molecules of scientific and societal value. Such advances provide the foundation for the pharmaceutical, agricultural, fine chemicals, materials science, environmental science, and energy industries and the fundamental tools for scientific research. The focus of this work on molecular processes also advances our basic knowledge of molecular structure and function, which in turn provides the foundation for the molecularization of science from molecular anthropology to molecular zoology. As evident from over 300 former coworkers trained in this program, many in leadership positions in academia and in industry, this research provides an exceptional training program for undergraduates, graduate students and post-doctoral fellows, including those from historically under-represented groups, and a source of inspiration and knowledge for others to use chemistry to address pressing and unsolved problems in medicine, materials, diagnostics and energy research.