New Strategies for Photoinduced Carbon Monoxide Releasing Molecules

犹他州州立大学化学与生物化学系的Lisa M.Berreau教授获得了化学系化学合成(SYN)项目的这一奖项，将开发一种全新类型的光致一氧化碳(CO)释放分子(PhotoCORM)。这些分子对于给予产生抗炎和抗细胞凋亡作用的少量CO，以及血管扩张和保护组织免受再灌注损伤具有重要意义。要进行的模块化设计包括使用3-羟基-4-吡喃酮单元作为CO释放基序。对吡喃酮和支撑性螯合配体的结构进行系统修饰的锌配合物的研究将有助于阐明影响结构/物理性质关系和CO释放反应性的化学因素。互补的计算和机理研究将有助于深入了解CO释放的反应途径，并将为后续几代基于吡喃酮的CO释放剂的设计提供指导。即将开发的新的光CORM具有用于生物和药物化学研究以及在化学合成中的应用的潜力。该项目与本科生和研究生的招聘和培训完全结合在一起，包括那些在科学界历来代表性不足的学生。学生将接受合成和光化学方面的培训，并将从与国内外合作者的互动中受益。

With this award from the Chemical Synthesis (SYN) program of the Chemistry Division, Professor Lisa M. Berreau of the Department of Chemistry & Biochemistry at Utah State University will develop a fundamentally new type of photoinduced carbon monoxide (CO) releasing molecules (photoCORMs). Such molecules are of significant interest for the administration of small amounts of CO that produces anti-inflammatory and antiapoptotic effects, as well as vasodilation and protection of tissues against reperfusion injury. The modular design to be pursued involves the use of a 3-hydroxy-4-pyrone unit as the CO release motif. Studies of zinc complexes wherein the structure of the pyrone and a supporting chelate ligand are systematically modified will enable elucidation of chemical factors that influence structure/physical property relationships and CO release reactivity. Complementary computational and mechanistic studies will provide insight into the reaction pathway involved in CO release and will provide guidance in the design of subsequent generations of pyrone-based CO release agents. The new photoCORMs to be developed have the potential for use in biological and medicinal chemistry investigations, as well as applications in chemical synthesis. This project is fully integrated with the recruitment and training of undergraduate and graduate students, including those from groups historically underrepresented in the sciences. Students will receive training in synthesis and photochemistry, and will benefit from interactions with domestic and international collaborators.