EAGER: A surface charge driven nanofluidic pump

1335946普拉卡什这项提案的总体目标是在生物和工程纳米流体的主动泵送原理的启发下，在开发纳米流体泵方面取得变革性的进展。在这个概念验证项目中，将尝试在通道壁上存在不对称表面电荷的情况下，在受限的纳米通道中建立电动水溶液电解质传输。这些实验将由计算模型(包括连续介质和分子动力学)来指导，以设计出一种概念验证的、新型的纳米流体泵。这个想法是基于生物系统中公认的想法，生物系统使用不对称电荷来移动水合离子，并与嵌入电极的纳米流体设备相结合，开发出一种新型的纳米流体泵。自那以后，在这项提议提出高风险、可能具有变革性的研究之前，没有建立这样的系统。这项工作将对纳米尺度流体动力学的进展产生重大影响，从而为设计各种应用的新型纳米流体装置开辟新的途径，如主要提案叙述中所述。通过在研究和教育之间采用多阶段整合，这个多学科的实验项目预计将使至少本科生和研究生，也许还有更广泛的受众，包括少数群体、代表性不足的群体、初中生和高中生，通过个人和小组实验室培训、课程作业、动手研讨会、外联和网络模块，接触到微流体和纳米流体，以影响未来科学家和工程师的教育。

1335946PrakashThe over-arching goal of this proposal is to provide transformative advances towards developing a nanofluidic pump inspired by principles of active pumping from biology and engineered nanofluidics. In this proof-of-concept project, an attempt will be made to establish electrokinetic aqueous electrolyte transport in a confined nanochannel in the presence of asymmetric surface charges on the channel walls. The experiments will be guided by computational models (both continuum and molecular dynamics) to engineer a proof-of-concept, novel, nanofluidic pump. The idea is based on well-established ideas in biological systems that use asymmetric charges to move hydrated ions and combine with a nanofluidic device with embedded electrodes to develop a novel nanofluidic pump. Since, no such system has been built before this proposal presents high risk, potentially transformative research. This work will have significant impact on advances in nanoscale fluid dynamics leading to new avenues for engineering novel nanofluidic devices for a variety of applications as described in the main proposal narrative. By using multi-stage integration between research and education, this multi-disciplinary experimental project is expected to give at a minimum undergraduate and graduate students and perhaps a much broader audience including minority, under-represented groups, middle and high school female students exposure to microfluidics and nanofluidics through individual and group lab training, coursework, hands-on workshops, outreach, and web modules for impact on education of future scientists and engineers.