EAGER: Microendoscopy-Guided Biopsy in Very Small Ducts

摘要#1351110 Eric J. Seibel在EAGER项目中，提出了一种内窥镜医疗器械的新工程设计。 这种新方法将允许在直径为1.7 mm的可弯曲和柔性内窥镜内包含工作通道。与传统内窥镜缩小用于照明、成像、冲洗和活检的单独通道不同，新方法将在提供冲洗和活检的工作通道的尖端放置一个超小型成像仪。这种新方法对临床成像具有变革性意义，对加速光学活检的发展至关重要。 工作通道将提供液体交换和组织真空、活检和回收的关键要求。测试将涉及活检装置，其将上皮粘膜抽吸到连接到近端的切割室中以进行活检取回。将使用合成体模和离体猪肺的测试结果以迭代方式修改活检装置。集成的显微内窥镜和活检装置将被制造和测试，用于内窥镜引导到特定部位进行活检。将标记的细胞和微球注射到管腔壁中，以使活检的准确性和充分性成为定量里程碑。

Abstract#1351110Eric J. SeibelIn this EAGER project a new engineering design for an endoscopic medical device is proposed. This new approach will allow a working channel to be included within an ultrathin and flexible endoscope of 1.7-mm diameter. Instead of shrinking the conventional endoscope of separate channels for illumination, imaging, flushing, and biopsy; the new approach will place an ultrasmall imager at the tip of a working channel that provides flushing and biopsy. This new approach is transformative for clinical imaging and critically helpful for accelerating the development of optical biopsy. The working channel will provide the key requirements of fluid exchange and tissue vacuum, biopsy, and retrieval. Testing will involve the biopsy apparatus, which is suction of the epithelial mucosa into a cutting chamber that is connected to the proximal end for biopsy retrieval. The biopsy apparatus will be modified in an iterative manner using test results from a synthetic phantom and ex vivo pig lung. The integrated microendoscope and biopsy apparatus will be fabricated and tested for endoscopic guidance to specific sites for biopsy. Fluorescently labeled cells and microspheres will be injected into the luminal wall so that accuracy as well as adequacy of the biopsy will be the quantitative milestones.