CAREER: New Metal Catalyzed Reactions for Trans-Alkynevinylation

通过这个职业奖，化学催化项目支持锡拉丘兹大学化学系丹尼尔·a·克拉克教授的研究。克拉克教授为炔的硅基乙烯化发展了新的催化方法。本研究的第一个目标是利用丰富的化学原料乙烯作为偶联伙伴，生产含有二烯的高取代环化合物。研究了乙烯对烷基硅乙烯化反应立体化学结果的影响。第二个目标探索使用乙烯基硼酸盐作为偶联伙伴与炔创建更复杂的系统。这种方法很可能消除废物流，因为不需要对起始材料进行预功能化。该研究的成功实施预计将对有机化学、农业化学、制药和材料工业等领域产生积极影响。CAREER奖还为教育项目提供支持；具体来说，就是在锡拉丘兹和北锡拉丘兹公立学校为科学、技术、工程和数学（STEM）教育工作者开设讲习班。克拉克教授项目的目标是为K-12教师提供可以在课堂环境中实施的讲座材料和化学实验。克拉克教授的项目符合雪城大学（SU）的愿景，即“行动中的奖学金”，这是SU对持续社区参与的承诺。

With this CAREER Award, the Chemical Catalysis Program supports the research of Professor Daniel A. Clark of the Department of Chemistry at Syracuse University. Professor Clark develops new catalytic methods for the silylvinylation of alkynes. The first objective of this research is to utilize ethylene, an abundant chemical feedstock, as a coupling partner to produce highly substituted cyclic compounds that contain a diene. The role of ethylene on the stereochemical outcome of silylvinylation of alkynes is carefully examined. The second objective explores the use of vinylboronates as coupling partners with alkynes to create more complex systems. This approach is likely to eliminate waste streams as no pre-functionalization of starting materials is required. The successful implementation of the proposed research is expected to positively impact the fields of organic chemistry and agrochemistry, pharmaceuticals, and the materials industry. The CAREER award also provides support for educational programs; specifically, the creation of workshops for Science, Technology, Engineering, and Mathematics (STEM) educators in the Syracuse and North Syracuse public schools. The goal of Professor Clark's program is to offer access to lecture materials and chemical experiments that can be implemented in a classroom environment by K-12 teachers. Professor Clark's program is in line with the vision of Syracuse University (SU) entitled: Scholarship in Action, a commitment from SU to sustained community engagement.