SusChEM: CAREER: Catalytic Methods for Direct Access to Tetrasubstituted Nitrogen-Containing Molecules

NSF化学部的化学催化(CAT)计划正在支持加州大学河滨分校的凯瑟琳·H·拉森教授的研究。该项目的重点是开发一系列新的催化剂，以在单一、高效的催化过程中制备含胺的四取代碳中心。这些反应最大限度地减少了废物，唯一的副产品是相当于水的一种。由此产生的分子构建块形成了治疗性天然产品、生物医学探针和药物的核心。推广活动融合了绿色化学原理，通过艺术将化学带给学生和更广泛的公众。拉森教授的项目开发了一步催化方法来合成含胺的四取代碳中心。一种双金属体系正被用来克服形成关键分子中间体所需的高能障碍，以直接获得高度受阻的化合物。该方法使用可持续的催化剂在一步内获得不对称的四取代碳，从而提供受阻的有机胺。拉森教授通过讲座、实验室课程、对女性科学参与河滨(WISER)俱乐部的演讲，以及融入河滨美术馆“漫步与奇迹”之旅的“艺术科学”项目，展示了绿色化学和催化的影响。后者通过对绘画、雕塑和其他媒体创作中涉及的化学物质进行触觉实验，激励社会经济贫困的二年级和五年级学生，提供对科学的积极反应。

The Chemical Catalysis (CAT) Program in the NSF Division of Chemistry is supporting the research of Professor Catharine H. Larsen at the University of California, Riverside. The project focuses on developing a new series of catalysts to prepare amine-bearing tetrasubstituted carbon centers in a single, efficient, catalytic process. The reactions minimize waste with the sole by-product being one equivalent of water. The resulting molecular building blocks form the core of therapeutic natural products, biomedical probes, and pharmaceuticals. The outreach activities integrate green chemistry principles, bringing chemistry to students and the wider public through art.Professor Larsen's project develops a one-step catalytic methods to synthesize amine-bearing tetrasubstituted carbon centers. A dual metal system is being used to overcome the high energy barrier required in forming key molecular intermediates for direct access to highly hindered compounds. The approach uses sustainable catalysts to access asymmetric, tetrasubstituted carbons in a single step to provide hindered organic amines. Professor Larsen showcases the influence of green chemistry and catalysis through lectures, laboratory courses, presentations to the Women in Science Engaging Riverside (WISER) club, and "The Science of Art" program, which is integrated into the Riverside Art Museum's "Walk and Wonder" tours. The latter outreach inspires socioeconomically disadvantaged 2nd- and 5th-grade students through tactile experimentation with the chemistry involved in the creation of paintings, sculptures, and other media, providing a positive reaction to science.