MRI: Acquisition of a mass spectrometer

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，明尼苏达大学的Viktor Nemykin教授及其同事Steven Berry、Venkatram Mereddy和Viktor zhdankin将获得具有电喷雾电离(ESI)、大气压化学电离(APCI)和大气压光电离(APPI)能力的微型TOFMS。通常，质谱仪是用于识别和表征嵌入在复杂基质中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些组分流入质谱仪，在那里它们被电离成母离子，并测量它的碎片离子及其质量。这种高度灵敏的技术可以检测和确定复杂混合物中的分子结构。作为一所以本科为主的机构，明尼苏达大学德卢斯分校的教职员工将本科生的研究经验作为其研究活动最重要的成果之一。拟议中的仪器将直接影响三年项目期间大量本科生和硕士学生的研究经验，并在未来几年影响更多。该仪器将用于课堂和研究活动。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)测定有机、无机和有机金属合成小分子的结构、稳定性和反应性；以及(B)研究用有机合成方法制备的潜在生物活性化合物。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Viktor Nemykin from University of Minnesota Duluth and colleagues Steven Berry, Venkatram Mereddy and Viktor Zhdankin will acquire a microTOFMS with electrospray inionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric-pressure photoionization (APPI) capabilities. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex matrices. In a typical experiment, the components flow into a mass spectrometer where they are ionized into the parent ion and its fragment ions and their masses are measured. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. As a primarily undergraduate institution, the faculty at the University of Minnesota Duluth embraces undergraduate research experiences as one of the most important outcomes of their research activities. The proposed instrument will directly impact the research experiences of a large number of undergraduate and master students within the three-year project period, and many more in years to come. The instrument will be used in classroom and research activities.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) determining structure, stability, and reactivity of small organic, inorganic, and organometallic synthetic molecules; and (b) investigating potentially bioactive compounds prepared using organic synthesis approaches.