EAGER: Non-invasive Cerbrovascular Regulation Assessment

PI：Mitra、Kunal 提案编号：1435511机构：佛罗里达理工学院标题：EAGER：非侵入性脑血管调节评估迫切需要一种便携式和客观的非侵入性工具来评估持续性脑震荡损伤（CHI）患者的生理性脑功能障碍。已知CHI会引起脑血流紊乱以及神经心理学（NP）症状。目前的临床评估完全依赖于NP测试，缺乏客观的诊断标准，不能表明实际脑损伤的存在。许多NP测试结果正常的患者被清除以恢复先前的活动，但实际上身体受损，并且更容易重复损伤。所提出的传感器和新的算法可以提供急需的工具，初步检测，评估，监测和康复的个人与CHI。脑震荡通常会导致物理性脑损伤和脑血流量（CBF）控制功能障碍，这通常无法通过当前的神经心理学测试方法检测到。用目前可用的工具难以客观测量功能障碍。这个问题将通过实施脑血氧饱和度和脑血流图（脑生物阻抗），连同新的算法，以评估控制CBF的机制进行研究。 本研究的主要目的是确定这两种易于实现的非侵入性设备是否可以组合使用，而不需要额外的传感器，以评估脑血管功能，并探索可用于临床评价的实验方案。本研究将使用健康志愿者，以建立基线标准并优化试验方案。研究方法包括以预定的间隔吸入环境空气和空气与CO2的混合物。将针对CO2浓度、吸入持续时间和重复吸入激发（即，趋势）。研究结果将用于制定方案和调整传感器参数，用于脑震荡后CBF控制受损的个体的未来研究。

PI: Mitra, Kunal Proposal Number: 1435511Institution: Florida Institute of TechnologyTitle: EAGER: Non-invasive Cerbrovascular Regulation AssessmentA critical need exists for a portable and objective noninvasive tool to evaluate physiological cerebral dysfunction in patients who have sustained concussive head injury (CHI). CHI is known to cause disturbances in brain blood flow as well as neuropsychological (NP) symptoms. Current clinical assessments rely entirely on NP testing, which lack objective diagnostic criteria and do not indicate the presence of actual brain injury. Many patients with normal NP test findings are cleared to resume previous activities, yet are in fact physically impaired and have heightened vulnerability to repeat injury. The proposed sensors and novel algorithms may provide crucially needed tools for initial detection, assessment, monitoring, and rehabilitation of individuals with CHI. Concussion often causes physical brain injury and dysfunctional control of cerebral blood flow (CBF), which is often undetected by current neuropsychological test methods. Objective measurement of dysfunction is difficult with currently available tools. This problem will be investigated by implementing cerebral oximetry and rheoencephalography (cerebral bioimpedance), together with novel algorithms, to evaluate mechanisms that control CBF. The primary objective of this research is to determine whether these two easily implemented noninvasive devices can be used in combination, without the need for additional sensors, to assess cerebrovascular function, and to explore experimental protocols that could be used in clinical evaluations. Healthy volunteers will be used in the study in order to establish baseline norms and optimize test protocols. The research methods include inhalation of ambient air and a mixture of air and CO2 at predetermined intervals. Sensor responses to the expected vasodilatory response from CO2 inhalation will be analyzed for the effects of CO2 concentration, duration of inhalation, and repeated inhalation challenges (i.e., trending). The results will be used to develop protocols and adjust the sensor parameters for future studies in post-concussive individuals with impaired CBF control.