RAPID response: Assessment of Potential Ecological and Health Impact of Coal Ash Spill in Dan River North Carolina

1440764 GuThis research demonstrates the application of a new，cost-effective toxicity evaluation method for water quality monitoring. 这项研究将包括丹河，最近的煤灰泄漏现场。 它对环境和公众健康保护具有重大益处。与领先的水质监测技术以及煤灰污染河水对环境和健康的影响有关的一系列协同增效的教育推广和公众教育方案和战略，将弥合科学研究、实地实施和公众健康保护之间的差距。它们将向各级广泛的受众介绍科学界快速应对灾害的技术、惠益以及社会和环境影响。拟议的研究将展示毒理基因组学支持的体外测定方案和方法平台的应用，该方案和方法平台可以成为及时和信息丰富的水质监测的有效毒性评估方法，这是卡罗莱纳煤灰泄漏等事件迫切需要的。这些结果将导致水修复功效评估的范式转变，从通常存在偏见和有限的化学信息的方法转变为更可靠的方法，确定现实的终点，更好地反映受体的实际风险。这将提供及时和有用的信息，以促进遏制和应对战略的制定，并帮助告知公众和政府与泄漏有关的任何潜在的生态和健康影响。

1440764GuThis research demonstrates the application of a new, cost-effective toxicity evaluation method for water quality monitoring. The study will encompass the Dan River, site of a recent coal ash spill. It has significant benefits to environmental and public health protection. The synergized arrays of education outreach and public education programs and strategies related to leading-edge water quality monitoring technology, as well as environmental and health implications of coal ash contamination of river water, will bridge the gap between scientific research, field implementation and public health protection. They will present the technology, benefits, and societal and environmental impact of rapid scientific community response to disasters to a wide range of audiences at various levels. The proposed study will demonstrate the application of a toxicogenomics-enabled in vitro assay scheme and methodology platform that can be an effective toxicity evaluation method for timely and informative water quality monitoring, as urgently needed by incidents like the Carolina coal ash spill. The results will lead to a paradigm shift in water remediation efficacy assessment from methods that suffer from often biased and limited chemical information to a more reliable method that identifies realistic endpoints and better reflects the actual risks to receptors. This will provide timely and useful information needed to facilitate containment and response strategies development and, to help inform the public and government of any potential ecological and health impacts associated with the spill.