Collaborative Research: Planning Grant: I/UCRC for Advanced Mammalian Biomanufacturing Innovation Center (AMBIC)

约翰霍普金斯大学、克莱姆森大学和特拉华大学提议成立一个新的由NSF支持的工业/大学合作研究中心(I/UCRC)，名为先进哺乳动物生物制造创新中心(AMBIC)，以应对美国生物制药制造面临的当前和未来挑战。先进哺乳动物生物制造创新中心(AMBIC)将汇集学术界、工业界和政府的领先生物技术专家，目标是在竞争前的研究水平上推进细胞培养制造创新。AMBIC代表着一个独特的机会，通过将领先的研究人员和创新者聚集在一起，实施变革性的产品和流程，从而解决美国生物制药制造中的技术挑战和瓶颈，从而使生物制药行业变得更强大、更健康、更具竞争力。通过这种方式，AMBIC将成为通过专注于哺乳动物细胞培养问题来保持国家在生物制药生产方面的卓越地位的关键催化剂。AMBIC的三个推动力如下：1.哺乳动物平台的基因组和细胞工程，目标是开发具有更高生产能力的先进平台。2.哺乳动物细胞的动员学和系统生物学，任务是获取组学数据，并实施哺乳动物生产平台的性能标准。3.优化生物反应器控制，以改善细胞性能，目标是表征代谢状态并实施先进控制。该项目将支持计划会议，以吸引生物制药行业和政府的合作伙伴参与AMBIC，并为该中心制定研究和教育计划。计划会议将有助于确定主要的研究挑战，并设计哺乳动物生物制造方面的尖端研究和教育计划。此外，AMBIC将建立和维持一条各级受过教育和积极进取的学生在生物制药制造和开发方面的职业发展渠道。与企业合作伙伴的合作将使学生能够解决该行业面临的最紧迫的问题。此外，AMBIC将致力于吸引和激励来自未被充分代表的少数群体的学生在生命科学、工程或相关的STEM领域追求职业生涯。通过系统生物学分析、新的细胞系开发和生物反应器优化，AMBIC将提供创新的解决方案，以提高生物制造效率。这些进展最终将有助于降低消费者的总体医疗成本，并使生物制药更容易负担得起，为更多的患者提供。

Johns Hopkins University, Clemson University, and the University of Delaware propose to form a new NSF-supported Industrial/University Cooperative Research Center (I/UCRC) entitled the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) to address current and future challenges faced by US bio-pharmaceuticals manufacturing. The Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) will bring together leading academic, industrial, and government biotechnologists with the goal of advancing cell culture manufacturing innovation at a pre-competitive research level. AMBIC represents a unique opportunity to address technology challenges and bottlenecks in US biopharmaceutical manufacturing by bringing together leading researchers and innovators to implement transformative products and processes that will lead to a stronger, healthier, and more competitive biopharmaceutical industry. In this way, AMBIC will be a critical catalyst towards maintaining national excellence in biopharmaceutical production by focusing on mammalian cell culture issues. The three thrusts of AMBIC are as follows:1. Genome and Cellular Engineering of Mammalian Platform with the goal of developing advanced platforms with improved production capabilities.2.`Omics and Systems Biology for Mammalian Cells with the task of acquiring ?omics data and implementing standards of performance for the mammalian production platform3.Optimizing Bioreactor Control for Improved Cellular Performance with the objective of characterizing metabolic states and implementing advanced controls. This project will support the planning meeting to engage partners from the biopharmaceutical industry and government to participate in AMBIC and develop a research and educational program for the center. A planning meeting will help to identify major research challenges and to design a cutting edge research and educational program in mammalian biomanufacturing. Furthermore, AMBIC will establish and maintain a pipeline of educated and motivated students at all levels for careers in biopharmaceutical manufacturing and development. Collaborations with corporate partners will enable the students to work on the most pressing problems that the industry faces. In addition, AMBIC will serve to engage and excite students from under-represented minority populations to pursue a career in life sciences, engineering, or related STEM fields. Through systems biology analysis, novel cell line development, and bioreactor optimization, AMBIC will provide innovative solutions to improve biomanufacturing efficiencies. These advances will ultimately serve to lower overall health care costs for consumers and make biopharmaceuticals more affordable and available for a greater number of patients.