GOALI: A Miniature Ion Chromatograph and Chromatography Imaging

在这个由化学系化学测量和成像计划资助的项目中，Purnendu Dasgupta教授和德克萨斯大学阿灵顿分校的学生正在开发可在现场使用的新一代小型便携式分析仪。该项目利用美国国家科学基金会的学术联系机会(GOALI)计划，与领先的离子色谱(IC)制造商Thermo Fisher Dionex(加利福尼亚州桑尼维尔)结成行业联盟。几名学生将有机会在制造商的工厂实习，行业科学家将共同指导学生建造一种微型、现场便携式、低占地和低功耗的离子色谱仪。更广泛的影响是通过开发将在许多应用中使用的现场可部署工具，以及通过包括独特和广泛的行业互动的本科生和研究生教育和培训来解决的。该项目有两个不同的广泛目标：虽然目前大多数阴离子分析都是通过离子色谱进行的，但设备仍然太重，消耗的电力太多，难以在现场轻松部署。本项目旨在开发一种小型、便携、低功耗的现场部署离子色谱仪。与填充柱不同，设想了一种抑制的开管(OT)IC，其中柱将包含一个完整的抑制器和导纳检测器，用于全功能的梯度抑制IC。此外，还将出现第二个导纳检测器。在该检测器之前，碱将渗入壁面并与第一检测器流出物混合；这一原理已知能够检测到非常弱的酸性阴离子，这在目前是不可能的。第二个目标是探索在液体和离子色谱中使用各种检测器和分离模式的扫描检测。玻璃、二氧化硅和聚合物柱对几种类型的检测器是透明的。扫描平台提供了一种廉价的高分辨率手段，以便在发生分离时查看柱内发生的分离。最终结果是，人们可以实时查看分离情况，并在原则上向洗脱液成分提供自动反馈，以改善分离情况。在多次扫描期间产生的丰富数据将使准确的量化实际上在完全分离发生之前实现。扫描检测将未洗脱的物质可视化，并提供柱子健康的诊断。最后，在梯度洗脱中，分析物的时间、位置和速度的三维地图有望提供本质上是色谱的、不依赖于检测器的识别标记。

In this project funded by the Chemical Measurement and Imaging program of the Chemistry Division, Professor Purnendu Dasgupta and students at the University of Texas at Arlington are developing a new generation of small portable analyzers that can be used in the field. This project uses the Grant Opportunities for Academic Liaison with Industry (GOALI) program of the NSF to form an industry alliance with a leading ion chromatography (IC) manufacturer, Thermo Fisher Dionex (Sunnyvale, CA). Several students will have an opportunity to intern at the manufacturer's facility and industry scientists will co-supervise students towards a building miniature, field-portable ion chromatographs of low footprint and low power. The broader impacts are addressed through the development of a field deployable instrument that will be used in many applications, and through undergraduate and graduate student education and training that includes unique and extensive industrial interactions. This project has two separate broad goals: While most anion analyses today are carried out by ion chromatography, the equipment is still too heavy and consumes too much power to be easily deployed in the field. This project seeks to develop a small, portable, low power consumption ion chromatograph instrument for field deployment. Rather than packed columns, a suppressed open tubular (OT) IC is envisioned where the column will contain an integral suppressor and admittance detector for fully functional gradient-capable, suppressed IC. Further, a second admittance detector will be present. Before this detector, a base will permeate through the wall and mix with the first detector effluent; this principle is known to enable detection of very weak acid anions, not presently possible. The second goal is to explore scanning detection in liquid and ion chromatography, using a variety of detectors and separation modes. Glass, silica and polymer columns are transparent to several types of detectors. A scanning platform provides an inexpensive high-resolution means to look at separations occurring inside columns as they occur. The net result is that one can look at separations in real time and, in principle, provide automated feedback to eluent composition to improve separations. The wealth of data generated during multiple scans will enable accurate quantification actually before complete separation occurs. Scanning detection visualizes what did not elute and provides a diagnostic of column health. Finally, in gradient elution, the three dimensional map of time location and speed of an analyte is expected to provide an identification marker that is intrinsically chromatographic and not detector-dependent.