UNS:Erythrocyte-derived optical nano-vesicles as photo-theranostic agents

PI：安瓦里，巴赫曼，提案号。当前位置[1509218]这项工作的独特贡献在于能够利用患者自身的红细胞制造纳米颗粒，从而延长循环时间，最大限度地减少生物相容性问题，从而使这些纳米颗粒能够与肿瘤相互作用。然后，光能可以与纳米颗粒一起产生热量，并在肿瘤上提供局部热疗，以摧毁它或增加化疗或放疗。个性化医疗具有巨大的潜力，这项工作可以为这一领域做出重要贡献。如何有效地治疗各种恶性肿瘤，使其副作用降到最低，仍然是现代医学的一个重要问题。个性化医疗提供了根据个体患者的遗传和免疫组成来指导和优化此类治疗的机会。本研究将开发装载荧光染料的鬼红细胞作为肿瘤细胞的荧光成像治疗剂，并诱导光热杀伤损伤。在异种移植小鼠模型中，红细胞将被一种抗体功能化以靶向肿瘤。在他的实验室里，PI有许多未被充分代表的学生。这项工作的各个方面将被纳入新的课程。

PI: Anvari, BahmanProposal No.: 1509218The unique contribution of this proposed work is the ability to engineer nanoparticles that can be made using the patient's own erythrocytes to extend the circulation time and minimize biocompatibility issues so that these nanoparticles can interact with tumors. Light energy can then be used with the nanoparticles to generate heat and provide localized hyperthermia at the tumor to destroy it or augment chemo or radiotherapy. Personalized medicine has great potential and this work can make important contributions to this field.Effective treatment with a minimum of side effects of various malignant tumors remains an important problem in modern medicine. Personalized medicine gives the opportunity to direct and optimize such treatment to individual patients based upon their genetic and immunological makeup. This proposal will develop ghost erythrocytes loaded with fluorescent dyes as theranostic agents to image cancer cells by fluorescence and also to induce photothermal killing damage. The erythrocytes will be functionalized with an antibody to target tumors in vivo in xenograft mouse models. The PI has had many under-represented students in his lab. Aspects of the work will be incorporated into a new class.