UNS: Coupled Flow-Chemistry Modeling of Thrombogensis in Human Ventricles

1511200(米塔尔)该提案的重点是通过计算了解血液在人体心脏中的流动。当心脏中的血液流动受到心肌梗死的干扰时，就有可能产生导致血液凝结的条件。这项拟议工作的新奇之处在于使用了计算模型，这些模型不仅能解释血液流动，还能解释血栓形成的详细生化过程。每年有数十万美国人被发现患有心肌梗塞，并可能从这项研究的结果中受益。尽管有几十年的研究，但心室流体动力学和凝血化学之间的复杂相互作用还没有被很好地了解。人们建议利用医学成像和计算流体力学的最新发展来模拟真实心脏模型中的血液流动，并研究流动与与左心室(LV)血栓形成相关的化学物质之间的耦合。有人建议使用医学成像来创建左心室的模型来模拟血液流动。由此得到的流场数据将用于模拟凝固级联中重要的物质的对流、扩散和反应，以及血小板的动力学和粘附性。该项目的具体目标是：(1)开发左室血栓形成的流动-化学耦合计算模型；(2)根据体内数据验证计算的血流动力学结果；(3)研究流动介导的血栓形成的机制；以及(4)使用模拟来检查替代的凝血途径和抗凝治疗的有效性。该项目将在流动化学耦合、成像到模型构建、混合(CPU-GPU)高性能计算模型、刚性耦合系统的双时间步长程序以及从体内数据验证CFD结果的新协议方面开辟新的天地。将开发的流动-化学耦合建模方法有望推动这一领域的最新技术，该领域仅限于简单、静止的容器几何和层流。

1511200(Mittal)The proposal is focused on the understanding of the flow of blood in the human heart using computations. When blood flow in the heart is disturbed by myocardial infraction, it is possible to create conditions that lead to blood clotting. The novelty of the proposed work is in the use of computational models that account not only for the flow, but also for the detailed biochemistry of clot formation. Hundreds of thousands of Americans each year are found to suffer from myocardial infraction and could potentially benefit from the results of this research.Despite many decades of research, the complex interplay between the ventricular fluid dynamics and the chemistry of coagulation is not well understood. It is proposed to take advantage of recent developments in medical imaging and computational fluid dynamics to simulate blood flow in realistic models of the heart, and to investigate the coupling between the flow and the chemistry associated with left ventricle (LV) thrombogenesis. It is proposed to use medical imaging to create a model of the LV to simulate blood flow. The resulting flow field data will be used to model the convection, diffusion and reaction of species known to be important in the coagulation cascade as well as platelet dynamics and adhesion. The specific objectives of the project are: (1) develop coupled flow-chemistry computational models of LV thrombus formation; (2) validate computational hemodynamic results against in-vivo data; (3) investigate the mechanisms of flow-mediated thrombogenesis; and (4) use simulations to examine alternate coagulation pathways and the effectiveness of anticoagulant therapies. This project will break new ground in flow-chemistry coupling, imaging-to-model construction, hybrid (CPU-GPU) high performance computing models, dual-time-stepping procedures for stiff coupled systems, and new protocols for validating CFD results from in-vivo data. The coupled flow-chemical modeling approach that will be developed is expected to advance the state-of-the-art in this arena that has been limited to simple, stationary vessel geometries and laminar flows.