Support for COMBINE 2015

数据交换标准对任何领域的发展都至关重要。它们使研究人员和从业者能够可靠地交换信息，应用各种工具来解决他们的问题，并复制科学结果。生物网络中的计算建模(COMBINE)创建于2010年，旨在组织系统生物学的标准化工作。这项工作包括用于数学建模的系统生物学标记语言(SBML)、用于描述路径的生物路径交换语言(BioPaX)、用于视觉表示的系统生物学图形符号(SBGN)和合成生物学开放语言(SBOL)。虽然合成生物学有许多独特的要求，但也有许多重叠的特征，如需要构建数学模型，描述途径，并提供可视化表示。这些努力的合作非常有意义，这样合成生物学社区就可以利用现有的标准，实现工具和其他基础设施的共享。联合组织每年举办两次研讨会，讨论生物学标准。这笔赠款的目的是支持学生、博士后学者和来自代表性不足群体的参与者参加将于2015年10月12日至16日在犹他州盐湖城的犹他大学举行的联合2015年。像这样的研讨会有助于在制定这些标准方面取得进展。目前，大多数标准化工作要么没有资金，要么只得到了非常有限的支持。事实上，这些标准的成功归功于许多人捐赠时间参与讨论、编写规范、担任标准编辑和参加研讨会。这些致力于标准开发的人中，有许多是居住在美国的学生，否则他们很难找到资金参加这次会议。因此，这笔赠款将帮助支付这些在美国的学生、博士后学者以及来自致力于系统和合成生物学标准的代表不足的团体的参与者的旅费、住宿费和注册费。这不仅对这些参与者来说是一次宝贵的经历，而且还将极大地增强我们的目标，即将合成生物学的研究人员与那些从事系统生物学工作的人聚集在一起，从而实现集成标准和共享软件和基础设施。智力价值：本次研讨会的主要目标是：(1)发展系统和合成生物学研究人员之间的协同关系。(2)更紧密地整合系统和合成生物学的标准制定。(3)对建模者和实验者的外展。(4)协调努力，倡导在出版物和档案数据库中使用标准。更广泛的影响：标准的发展有可能产生巨大的更广泛的影响。标准使研究人员能够共享模型和软件工具。它们提高了科学性，因为以标准编码的结果更容易重现。此外，系统和合成生物学在健康方面都有许多潜在的应用，例如更好地了解疾病和开发新药。这次工作坊也将是一次宝贵的教育经验，为学生参与者。

Standards for data exchange are critical to the development of any field. They enable researchers and practitioners to exchange information reliably, apply a variety of tools to their problems, and reproduce scientific results. The COmputational MOdeling in Biology NEtwork (COMBINE) was created in 2010 to organize standardization efforts for systems biology. This effort includes, among others, the systems biology markup language (SBML) for mathematical modeling, the biological pathways exchange language (BioPaX) for describing pathways, the systems biology graphical notation (SBGN) for visual representations, and the synthetic biology open language (SBOL). While synthetic biology has many unique requirements, there are also a lot of overlapping features such as the need to construct mathematical models, describe pathways, and provide visual representations. It makes a lot of sense for these efforts to collaborate, such that, the synthetic biology community can leverage existing standards enabling the sharing of tools and other infrastructure. The COMBINE organization holds two workshops per year to discuss standards for biology. The purpose of this grant is to support travel expenses for students, postdoctoral scholars, and participants from underrepresented groups to attend COMBINE 2015 to be held at the University of Utah in Salt Lake City, UT from October 12th to 16th, 2015. Workshops like this one are instrumental in making progress in the development of these standards. Currently, most standardization efforts are either unfunded or only have very limited support. Indeed, the success of these standards has been due to the donation of time from many individuals to participate in discussions, write specifications, serve as standard editors, and attend workshops. Many of these individuals working on the development of standards are students based in the US who would otherwise find it difficult to find the funds to attend this meeting. Therefore, this grant would help support travel, lodging, and registration expenses for these US-based students, postdoctoral scholars, and participants from underrepresented groups working on systems and synthetic biology standards. Not only would this be a valuable experience for these participants, but it would also greatly enhance our goal of bringing together researchers in synthetic biology with those working in systems biology leading to integrated standards and shared software and infrastructure. Intellectual Merit: The major goals of this workshop are: (1) Develop synergistic relationships between systems and synthetic biology researchers. (2) A tighter integration of standard development for systems and synthetic biology. (3) Outreach to modelers and experimentalists. (4) A coordinated effort to advocate the use of standards in publications and archival databases. Broader Impacts: The development of standards has the potential for tremendous broader impact. Standards enable researchers to share models and software tools. They improve science in that results encoded in standards are more readily reproducible. Furthermore, both systems and synthetic biology have numerous potential applications in health, such as a better understanding of diseases and the development of new drugs. This workshop will also be a valuable educational experience for the student participants.