EAGER: Non-invasive Sensing of Superficial Organ Tissue via Conforming Multi-parametric Microfluidic Organ Biosensors (MMOBs): Shifting the Paradigm for Organ Assessment

派：约翰逊，布莱克建议编号：1650601个供移植的器官，如肾脏，供不应求。目前还没有预测移植器官健康状况的好方法。目前的做法是不客观的。该项目将使用当前最先进的方法制造装置，这些装置将安装在特殊仪器中，用于使用传感器获得重要的测量结果，这些传感器将作为该项目的一部分制造。其目标是，这样的测量将使器官移植程序的健康评估工作不再是猜测工作。拟议项目的目标是制造一种符合和灵活的传感器，该传感器将适应于体外器官表面(实验中为猪肾)以获得电阻抗数据，并使用微流控装置测量灌流液中的生物标志物。该项目将使用先进的3D结构光扫描制造方法和基于挤压的添加剂制造方法来制造共形(形状适配)微流控器官生物传感器。这种基于传感器的浅层组织基质中生物标记物和阻抗特征的识别有望与器官健康相关。该项目将提供一个教育机会，创建一个为期两周的研讨会，培训学生生物医疗设备制造。教育福利将通过一个由教职员工评审的生物制造者博览会进行评估。

PI: Johnson, Blake Proposal Number: 1650601 Organs for transplantation, such as kidneys, are in short supply. Good measures that predict the health status of organs targeted for transplantation are not available. The current approach is not objective. This project will use current state of the art methods to make devices that will be attached to live kidneys in a special apparatus for obtaining important measurements using sensors that will be fabricated as part of the project. The goal is that such measurements will take the guess work out of the health assessment of the organ transplantation procedure. The goal of the proposed project is to fabricate a conforming and flexible sensor that will be adaptive to ex vivo organ surfaces (the porcine kidney in the experiments) for obtaining electrical impedance data, and measure biomarkers in perfused fluids using a microfluidic arrangement. The project will use advanced fabrication approach of 3D structured light scanning and extrusion-based additive manufacturing methodology for fabricating conformal (form-fitting) microfluidic organ biosensors. This sensor-based identification of biomarkers and impedance signatures in superficial tissue matrix is expected to correlate with organ health. The project will provide an educational opportunity by creating a two-week workshop which will train students in biomedical device manufacturing. Educational benefits will be assessed through a faculty-judged BIO-Maker fair.