Anion-driven recognition and assemblies of shape-persistent cyanostar macrocycles

分子识别和自组装是制造复杂结构材料和组装功能系统的有力方法，用于环境修复，药物递送和生物医学传感。 印第安纳州大学的Flood教授研究分子如何相互作用，以增加我们对控制分子识别和自组装的因素的基本理解。该项目还提供学生培训，使用3D打印分子来增强科学理解，以及技术转让的机会。在NSF化学部大分子，超分子和纳米化学计划的支持下，Flood教授进行研究，以了解控制阴离子驱动的形状持久大环识别和组装的因素。 该项目有三个具体目标。目的1研究了溶液中羟基阴离子与氰基大环化合物形成配合物的影响因素。 目标二是建立阴离子驱动结合与模板导向合成之间的关联，并建立分子开关的原型。目标3致力于制定规则，指导将氰基星形物组装成十二面体，使其能够高保真制备。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Molecular recognition and self-assembly are powerful approaches to fabricate materials of complex architecture and to assemble functional systems for applications in environmental remediation, drug delivery, and biomedical sensing. Prof. Flood at Indiana University studies how molecules interact with each other in order to increase our fundamental understanding of the factors governing molecular recognition and self-assembly. This project also provides student training, usage of 3D printed molecules to enhance scientific understanding, and opportunities for technology transfer. With the support from the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Division of Chemistry, Professor Flood conducts research to understand the factors controlling the anion-driven recognition and assemblies of shape-persistent macrocycles. There are three specific aims in this project. Aim 1 focuses on examining the factors that affect the formation of complexes between hydroxyanions and cyanostar macrocycles in solution. Aim 2 seeks to establish the correlation between the anion-driven binding and template-directed synthesis and create prototypes of molecular switches. Aim 3 strives to develop the rules governing the directed assembly of cyanostars into dodecahedra enabling their high-fidelity preparation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.