Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), Indiana University

该奖项支持由印第安纳大学、圣母大学和普渡大学共同努力的生物分析计量学产学-大学合作研究中心的规划。这次会议将汇集由分析仪器制造商、制药公司、临床医生、学术研究人员和其他利益相关者组成的全国联盟，并将他们团结在一起，共同致力于设计和构建新的、行业关键的化学测量和生物分析系统。需要这些系统来解决美国研发中的一个根本差距，即完全识别、表征和跟踪人类细胞内的生物分子并了解它们的许多复杂相互作用的能力。如果成立，从该中心剥离的技术将对药物发现、分子诊断、临床生物技术和其他领域产生直接和切实的好处。此外，该中心设想的能力对于实施其他长期健康目标是必要的，例如精准医疗。除了这一知识转移，该中心还将帮助培训一支新的和多样化的生物分析工作队伍。规划工作的结果将成为向国家科学基金会提出生物分析计量学中心的建议的基础。基因组学、蛋白质组学、代谢组学和生物信息学为研究生物系统提供了一个整体框架，其应用范围从生物系统的基础研究到个性化医学的诊断和治疗的设计和使用。然而，为了实现这些技术的前景，我们必须增加对蛋白质、代谢物和其他生物分子物种的分析深度，超过目前的限制，从而减少已检测到的、但未识别的被称为生命黑暗分子的物种的比例。这项计划拨款为生物分析计量中心(CBM)奠定了基础，加入了印第安纳州、圣母大学和普渡大学的专业知识。规划活动将汇集分析仪器制造商、制药公司、临床从业者以及分析科学和工程领域的领先学术研究团体。除了技术目标，CBM还将：(A)使技术和知识转移到工业部门；(B)加强专门为增加STEM劳动力多样性而设计的研究生和本科教育活动；以及(C)通过将研究纳入现有的本科和研究生课程，对化学、生物、计算机科学和工程课程提供有价值的更新。

This award supports planning for an Industry-University Collaborative Research Center for Bioanalytic Metrology, a joint effort of Indiana University, the University of Notre Dame, and Purdue University. The meeting will bring together a national coalition of analytical instrument makers, pharmaceutical companies, clinical practitioners, academic researchers, and other stakeholders, and unite them in a mission to design and build new, industry-critical systems for chemical measurement and bioanalysis. These systems are needed to address a fundamental gap in U.S. research and development; namely, the ability to fully identify, characterize, and track biological molecules within human cells and understand their many complex interactions. If established, the technical spin-offs from the center will have direct and tangible benefits for drug discovery, molecular diagnostics, clinical biotechnology, and other areas. Moreover, the capabilities envisioned by the center are necessary for the implementation of other long-term health objectives, such as precision medicine. In addition to this knowledge transfer, the center will also help train a new and diverse bioanalytical workforce. The outcomes of the planning exercise will form the basis of a proposal to the National Science Foundation for the Center for Bioanalytic Metrology. Genomics, proteomics, metabolomics and bioinformatics provide a holistic framework to study biological systems with applications ranging from fundamental studies of biological systems to the design and use of diagnostics and therapeutics for personalized medicine. To realize the promise of these technologies, however, we must increase the depth of analysis of proteins, metabolites and other biomolecular species beyond current limits, thus reducing the fraction of detected?but unidentified?species known as the ?dark molecules of life.? This planning grant lays the groundwork for a Center for Bioanalytic Metrology (CBM), joining expertise at Indiana, Notre Dame, and Purdue. Planning activities will bring together analytical instrument makers, pharmaceutical companies, clinical practitioners, and leading academic research groups in analytical sciences and engineering. In addition to the technical objectives, the CBM will also: (a) enable technology and knowledge transfer to the industrial sector, (b) enhance graduate and undergraduate education activities specifically designed to increase diversity of the STEM workforce, and (c) provide valuable updates to chemistry, biology, computer science, and engineering curricula through the incorporation of research into existing undergraduate and graduate classes.