CSBR: Living Stocks Support for the Peromyscus Genetic Stock Center

南卡罗来纳大学被授予一项奖项，以支持Permyscus基因股票中心(PGSC)。属的动物(通常指鹿鼠、白足鼠、沙滩鼠等)是NSF支持的研究人员和其他研究人员的首选模型，这些研究人员研究进化、适应和应激反应、行为、生理学、宿主-寄生虫相互作用、微生物组相关研究等。PGSC维护和分配远交配的Permyscus种群。此外，它还提供各种生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求开展小规模研究项目，以满足外部研究人员的研究需要。鉴于科学上对透明度和再现性的持续需求，PGSC提供了经过验证的质量、健康、遗传和生理状态的一致和不间断的动物供应。PGSC也是Permyscus相关研究的焦点，并为本科生和研究生以及其他研究人员提供使用Permyscus进行研究的培训。鹿、鼠和同属物种是最常见的北美本土哺乳动物。它们的分布范围从阿拉斯加到中美洲，分布在许多自然栖息地。由于数量丰富，这些动物构成了北极圈陆地生态系统的主要组成部分。PGSC保留了遗传和表型变异，这些变异来自于Permyscus属野生鹿鼠种群的地理变异。这些种群为研究自然种群中的基因型与表型关系、局部适应和进化提供了关键资源。自然选择和适应的一些最明显的证据来自对鹿鼠的研究。Permyscus已经成为研究物种形成、适应和应激反应、生理和进化背景下的行为适应、宿主-寄生虫相互作用、微生物组相关研究等主要生物学过程的首选模型。该种群中心通过为定量遗传和基因组分析提供活种群来识别生态上重要的适应性表型变异的潜在基因，并预测在空间可变和时间变化的环境中的种群进化反应，从而使这些研究成为可能。Permyscus Genetic Stock Center(PGSC)维护和分发Permyscus的近交种群和几个用于研究的行为和毛色突变体。此外，它还向调查人员提供各种生物样本，如新鲜、冷冻和保存的组织、DNA、粪便和血液样本，并应外部要求开展小规模研究项目，以满足调查人员的研究需要。PGSC还通过每年出版两次的时事通讯《PeroTimes》和PGSC网站(www.pgsc.Cas.sc.edu)作为Permyscus相关信息的信息交换中心。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the University of South Carolina to provide support for the Peromyscus Genetic Stock Center (PGSC). Animals of the genus Peromyscus (commonly referred to as deer mice, white footed mice, beach mice, etc.) are a model of choice for NSF-supported and other investigators that study evolution, adaptation and stress response, behavior, physiology, host-parasite interactions, microbiome-associated studies and others. The PGSC maintains and distributes outbred stocks of Peromyscus. In addition, it provides biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate the research needs of external investigators. In view of the continuing need for transparency and reproducibility in science, the PGSC provides a consistent and uninterrupted supply of animals with verified quality, health, genetic and physiological status. The PGSC also operates as a focal point for Peromyscus associated research and provides training for undergraduate and graduate students, and other investigators using Peromyscus in research.The deer mouse Peromyscus maniculatus and congeneric species are the most common native North American mammal. They range from Alaska to Central America and occur in many natural habitats. Because of their abundance, these animals constitute a major component of nearctic terrestrial ecosystems. The PGSC maintains genetic and phenotypic variants drawn from the geographic variation present in wild populations of deer mice in the genus Peromyscus. These stocks provide critical resources for the study of genotype to phenotype relationships, local adaptation, and evolution in natural populations. Some of the clearest evidence of natural selection and adaptation have come from studies of deer mice. Peromyscus has emerged a model of choice for the study of major biological processes such as speciation, adaptation and stress response, behavior adaptation in the context of physiology and evolution, host-parasite interactions, microbiome-associated studies and others. The stock center enables these studies by providing living stocks for quantitative genetic and genomic analyses to identify the genes underlying ecologically important, adaptive phenotypic variation and make predictions about population evolutionary response in a spatially variable and temporally changing environment. The Peromyscus Genetic Stock Center (PGSC) maintains and distributes outbred stocks of Peromyscus and several behavioral and coat-color mutants for research. In addition, it provides investigators with biological samples of various species, such as fresh, frozen and preserved tissues, DNA, fecal and blood samples and in response to external requests performs small-scale research projects to facilitate investigator's research needs. The PGSC also functions as a clearing-house for Peromyscus associated information through the 'Perotimes', a newsletter that is published twice a year, and the PGSC website (www.pgsc.cas.sc.edu).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.