Meeting: 2018 pre-Association of Biology Laboratory Educators (ABLE) meeting hands-on workshop for introducing CRISPR-Cas9 technology to undergraduate instructors

使用CRISPR-Cas9和其他可编程核酸酶的基因组工程和编辑技术正在迅速进入主流分子生物学研究。这些技术的出现对生物科学教师提出了一个重大挑战，即提供吸引人的有效方式将这些技术引入他们的课堂。该讲习班旨在向教师介绍CRISPR-CAS9技术在信息流和分子生物学中心法则的背景下，使这些新技术能够整合到生物科学框架中。研讨会参与者将发展设计和使用基因组工程和编辑的动手技能，以及将这些技术纳入其机构课堂讨论的方法。该奖项支持2018年6月16日至18日在俄亥俄州哥伦布市的俄亥俄州立大学举行的为期3天的研讨会，内容是为来自不同类型机构的本科生教师开发和实施CRISPR-Cas9技术，作为生物学实验室教育工作者协会(ABE)的前奏。教师将从所有类型的本科院校招聘，包括少数族裔服务院校和两年制院校。教师参与者将共同努力(A)熟悉与CRISPR-Cas9技术有关的背景知识和实验室技能，(B)将该技术的不同方面带入他们的课堂/实验室，(C)讨论并创建适合不同类型课堂/实验室的教学模块，以及(D)培养和支持将在其课堂/实验室传播基因工程/编辑技术并进行创新的本科生教育工作者。具体地说，会议将鼓励在生物信息流和分子生物学中心法则的背景下向本科生教授CRISPR-CAS9技术。传播计划包括在CURE Net(https://curenet.cnsutexas.edu)，)上张贴研讨会材料，这是一个基于课程的本科生研究经验(CURE)的储存库。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Genome engineering and editing technologies using CRISPR-Cas9 and other programmable nucleases are rapidly entering mainstream molecular biology research. The emergence of these technologies presents a significant challenge to biological science instructors to provide engaging and effective ways to introduce these technologies into their classrooms. This workshop aims at introducing CRISPR-Cas9 technology to instructors in the context of information flow and the Central Dogma of Molecular Biology, allowing integration of these new technologies into the biological sciences framework. Workshop participants will develop hands-on skills for designing and using genome engineering and editing, and methods for incorporating these technologies into classroom discussions at their institutions.This award supports a 3-day workshop from June 16-18, 2018 at The Ohio State University in Columbus, Ohio on the development and implementation of CRISPR-Cas9 technology for undergraduate instructors from different types of institutions as a prelude to the Association of Biology Laboratory Educators (ABLE). Faculty will be recruited from all types of undergraduate institutions, including minority-serving institutions and two-year institutions. Faculty participants will work together to (a) become conversant with background knowledge and lab skills relating to CRISPR-Cas9 technology, (b) bring different aspects of the technology into their classrooms/labs, (c) discuss and create pedagogical modules suitable to different types of classrooms/labs, and (d) foster and provide support to undergraduate educators who will disseminate gene engineering/editing technologies and make innovations in their classrooms/labs. Specifically, the meeting will encourage the teaching of CRISPR-Cas9 technologies to undergraduates in the context of biological information flow and the Central Dogma of Molecular Biology. Dissemination plans include posting workshop materials on CURE net (https://curenet.cnsutexas.edu), a repository of course-based undergraduate research experiences (CUREs).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.