MRI: Acquisition of an Inductively Coupled Plasma Mass Spectrometer (ICP-MS) System to Enable Elemental Analysis in Research, Training and Education

该奖项旨在购买具有激光消融和液相色谱能力的电感耦合等离子体质谱仪(ICP-MS)。这个电感耦合等离子体质谱系统将测量单个哺乳动物细胞以及复杂的液体和固体样品中存在的几乎所有元素及其同位素的浓度。研究工作将解决中南部平原地区的核心问题：医疗保健技术、环境/人口互动、可再生能源和水质。该工具将促进俄克拉荷马大学(OU)、俄克拉荷马州立大学(OSU)和塔尔萨大学(TU)之间的合作。将通过与Quapaw部落环境办公室有关的水质问题研究项目与俄克拉荷马部落民族进行协调，通过焦油溪超级基金网站与Quapaw部落环境办公室有关，通过大湖流域理事会与迈阿密、渥太华、怀安多特、肖尼、东肖尼、莫多克、夸劳、皮奥里亚和Seneca-Cayuga民族有关的研究项目进行协调。俄克拉荷马州的高中教师将通过NSF-RET计划“从事生物分析工程研究和教学的农村教育者”参与，该计划针对的是俄克拉何马州被认为是服务不足的农村学生和教师群体。将资助的电感耦合等离子体质谱仪器是PerkinElmer NexION2000型电感耦合等离子体质谱仪，具有各种分析能力。单个哺乳动物细胞将通过使用Asperon喷雾室单独引入电感耦合等离子体质谱仪进行分析。电感耦合等离子体质谱仪将设在俄亥俄州诺曼市斯蒂芬森生命科学研究中心的俄勒冈大学质谱学核心设施。将涉及的具体研究主题包括：1)纳米材料和药物与单个细胞的相互作用，以及细胞-金属代谢行为的评估；2)重建史前和现代生态系统中生物的种群动态、流动性和连通性；3)增强可再生能源材料的性能以及改善碳氢化合物系统；以及4)动态生态系统中生物-金属相互作用的表征，以保护人类健康和改善水质。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is to purchase an Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) with Laser Ablation and Liquid Chromatography capabilities. This ICP-MS system will measure the concentration of nearly all elements and their isotopes present in single mammalian cells, as well as complex liquid and solid samples. Research efforts will address core concerns of the south-central Plains region: healthcare technology, environment/population interactions, renewable energy, and water quality. This instrument will enable the collaborations among the University of Oklahoma (OU), Oklahoma State University (OSU) and the University of Tulsa (TU). Coordination with Oklahoma Tribal Nations will occur via research projects related to water quality issues pertinent to the Quapaw Tribal Environmental Office through the Tar Creek Superfund Site, and the Miami, Ottawa, Wyandotte, Shawnee, Eastern Shawnee, Modoc, Quapaw, Peoria and Seneca-Cayuga Nations through the Grand Lake Watershed Council. Oklahoma high school teachers will be engaged through the NSF-RET program "Rural Educators Engaged in Bioanalytical Engineering Research and Teaching" which targets rural students and teachers who are considered an underserved group in Oklahoma. The ICP-MS instrument to be funded is a PerkinElmer NexION2000 ICP-MS with various analytical capabilities. Single mammalian cells will be analyzed by being introduced individually into the ICP-MS using an Asperon Spray Chamber. The ICP-MS will be located at the OU Mass Spectrometry Core Facility, Stephenson Life Science Research Center, Norman, OK. The specific research topics to be addressed are: 1) Interactions of nanomaterials and drugs with individual cells, as well as assessment of cellular-metal metabolic behavior; 2) Reconstruction of population dynamics, mobility, and connectivity of organisms in prehistoric and current ecosystems; 3) Enhancement of renewable energy material performance as well as improvement of hydrocarbon systems; and 4) Characterization of organism-metal interactions within dynamic ecosystems to protect human health and improve water quality. aThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.