PDB Management by The Research Collaboratory for Structural Bioinformatics

结构生物信息学研究合作实验室（RCSB）蛋白质数据库（PDB）的使命是维持一个独特的可查找-可访问-可互操作-可重复使用（FAIR）的三维（3D）生物分子结构信息活数据资源。PDB结构是生命的分子。了解生物大分子的三维结构（形状），它们是如何随时间进化的，以及它们的功能，对于理解包括基础生物学在内的关键科学领域至关重要；人类、动物和植物的健康和疾病；粮食和能源生产；以及其他与全球繁荣和环境可持续性有关的话题。结构数据对生物制药和生物技术公司同样重要，推动新疗法、生物材料和医疗设备的发现。RCSB PDB服务跨越整个PDB数据生命周期。档案管理/访问服务保护超过137,000个生物大分子3D结构的单一全球档案，估计更新成本接近140亿美元。沉积/生物固化和数据探索服务支持全球30,000多名数据贡献者和100多万数据用户。PDB通过在生物功能、生化途径、细胞过程、疾病状态和分子进化的背景下整理、整合和传播生物分子结构信息，在维护开放获取的全球数据资源方面具有19年的科学和技术领导历史，已成为生物学和医学研究和教育的核心。支持研究（rcsb.org）和教育（pdb101.rcsb.org）的PDB网站在原子水平上促进对基础生物学、生物医学和能源的三维分子理解。获取PDB数据和RCSB PDB服务将继续推动从农业到动物学等科学学科的专利申请、药物发现和开发、创新研究的发表、改变生活的生物制药产品的开发以及新美国公司的成立。RCSB PDB外展、教育和培训工作利用了PDB数据和RCSB PDB员工的专业知识。超过62万名研究人员、教育工作者、学生和公众使用外展/教育服务。支持基础生物学探索的在线材料；生物医学;能源;生物技术药物发现；以及科学、技术、工程和数学（STEM）教育，被研究人员、教育工作者、学生和公众所消费。RCSB PDB教育资源是为家庭和教室的全球重用而设计的，只需要适度的台式电脑，智能手机或数字打印机就可以体验项目在线产品的全部影响。这些免费的材料都在pdb101.rcsb.org上，包括流行的分子月系列，它突出了分子的结构和功能，以及向广大读者介绍结构生物学工具的PDB数据理解指南。RCSB PDB还为高中和大学教育工作者和学生制作和分发在线课程材料，解释分子结构如何为基础生物学、医学、能源、生物技术和药物发现提供信息，重点关注全球公共卫生问题。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The mission of the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) is to sustain a unique Findable-Accessible-Interoperable-Reusable (FAIR) living data resource of three-dimensional (3D) biomolecular structure information. PDB structures are the molecules of life. Knowledge of 3D structures (shapes) of biological macromolecules, how they evolved with time, and their functions are essential for understanding critical areas of science, including fundamental biology; health and disease of humans, animals, and plants; food and energy production; and other topics of concern to global prosperity and environmental sustainability. Structure data are equally important for biopharmaceutical and biotechnology companies, driving discovery of new therapeutics, biomaterials, and medical devices. RCSB PDB services span the entire PDB data lifecycle. Archive Management/Access services safeguard this single global archive of over 137,000 3D structures of biological macromolecules, with an estimated replacement cost of nearly $14 billion. Deposition/Biocuration and Data Exploration services support over 30,000 data contributors and over 1 million data users worldwide. The PDB has a 19-year history of scientific and technical leadership in sustaining an open-access global data resource that has become central to research and education in biology and medicine, by curating, integrating, and disseminating biomolecular structure information in the context of biological function, biochemical pathways, cellular processes, disease states, and molecular evolution. RCSB PDB websites supporting research (rcsb.org) and education (pdb101.rcsb.org) foster a molecular understanding of fundament biology, biomedicine, and energy in three-dimensions at the atomic level. Access to PDB data and RCSB PDB services will continue to drive patent applications, drug discovery and development, publication of innovative research, in scientific disciplines ranging from Agriculture to Zoology, development of life-changing biopharmaceutical products and formation of new US companies. RCSB PDB outreach, education, and training efforts leverage PDB data and RCSB PDB staff expertise. More than 620,000 researchers, educators, students, and members of the public use the Outreach/Education services. Online materials supporting exploration of fundamental biology; biomedicine; energy; biotechnology drug discovery; and Science, Technology, Engineering, and Mathematics (STEM) education, are consumed by researchers, educators, students, and the public. RCSB PDB educational resources are designed for global reuse in homes and classrooms, requiring only modest desktop computers, smartphones, or digital printers to experience the full impact of the project's online offerings. These free-of-charge materials are hosted at pdb101.rcsb.org, including the popular Molecule of the Month series that highlights the structure and function of molecules, and the Guide to Understanding PDB Data that introduces structural biology tools to a broad audience. RCSB PDB also produces and distributes online curricular materials for high school and college educators and students, explaining how molecular structures inform fundamental biology, medicine, energy, biotechnology, and drug discovery, with a focus on global public health concerns.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.